699 



Addendum 



Baccatine A (entry 1114) has been shown to be a 

 mixture of enniatins A and B.'"' 



A partial structure has been advanced for PA-114-B-1 

 (entry 729).''- It is C^sHtjiOioNi,: 



OH 



/ 

 C — L-Thre 



II I 



O O 



I 

 0==C — L-a-Phenylglycine- 



"-N 



L-Proline 

 Sarcosine 



p-Dimethylamino- 

 phenylalanine 



5-Hydroxymethyl- 

 -D-a-Aminobutyric Acid — hydroxyproline 

 (perhaps) 



PA-114-B-3, a minor component of this synergistic com- 

 plex, contains all the same components except sarcosine. 

 It seems to contain another N-methyl amino acid instead. 

 Other synergistic complexes of this sort are streptogramin, 

 staphylomycin, ostreogrycin and mikamycin. These were 

 classified as follows: 



I'lG. E. HaU, Chem. and Ind., 1270 (1960). 



I'-D. C. Hobbs and W. D. Celmer, Nature 187 598 (1960). 



