Pfizer Handbook of Microbial Metabolites 704 



A b-type cytochrome has been isolated from the fungus 

 Sclerotiana libertiana and identified. ^^^ 



Protoporphyrin IX has been isolated from bacterial 

 catalase and characterized. ^^^ 



Addition of S-aminolevuHnic acid to cultures of pro- 

 pionibacteria caused large increases in the production of 

 porphyrins, but no rise in vitamin Bjo production, in- 

 dicating divergent biosynthetic routes."^ 



The structure of the antifungal pigment prodigiosin 

 has been proved by synthesis. -°° It is 



OCH 



and is thus the second natural product containing a 2,2'- 

 dipyrrole skeleton, vitamin Bjo being the other. 



A streptomycete has been found w^hich produces iso- 

 butyropyrrothine, orange-red antibiotic crystals, m.p. 



228 



o . 200a 



CH3 



/ 



S- -C=C— NH— CO— CH 



sec CH3 



C N O 



H 



CH3 



Aureothricin, thiolutin, a colorless base, and a heptaene, 

 hamycin, also were produced. 



^^" Tateo Yamanaka, Takehazu Horio and Kazuo Okunuki, Biochim. 

 et Biophys. Acta 40 349 (1960). 



1"* Steve Miller, Davis Hawkins and Robert P. Williams, /. Biol. 

 Chem. 235 3280 (1960). 



1^^ G. V. Pronyakova, Biokhimiya (English translation) 25 223 

 (1960). 



'°° Henry Rapoport and Kenneth G. Holden, /. Am. Chem. Soc. 82 

 5510 (1960). 



2oo« D. S. Bhata, R. K. Hulyakar and S. K. Menon, Experientia 16 

 504 (1960). 



