705 Addendum 



g. INDOLES 



The structure previously proposed for echinulin has 

 been confirmed, the only reservation being possible ex- 

 change of the groups in the 5 and the 7 positions of the 

 indole nucleus.-''^ 



926a Lysergic Acid Amide (Ergine), CieHiyONa (Monomethanolate), 

 m.p. 130-135° (efferv.), resolidifies 140°, m.p. 190° with 

 previous dec. 



926b Isolysergic Acid Amide (Isoergine), CicHi-ONg. 



937a Lysergic Acid Methylcarbinolamide, CisHo^OoNg, colorless 

 prisms, m.p. 135° (dec), [aW +29° ±2° (--1.0 in 

 dimethylf ormamide ) . 



937b Isolysergic Acid Methylcarbinolamide, C18H21O0N3, not crystal- 

 Une. 



A yield of about 2 g. per liter of the above alkaloids was 

 produced by Claviceps paspali Stevens T. Hall growing in 

 submerged culture.-"- A partial structure is shown for 

 the carbinolamide isomer corresponding to lysergic acid: 



CH3 



NH— C— OH 



/ I 

 0=C H 



O 



N— CH3 



Another new ergot alkaloid, molliclavine, has been 

 reported : -"^ -"* 



-°^ Franco Piozzi, Giuseppe Casnati, Adolfo Quilico and Cesare 

 Cardani, Gazz. chim. ital. 90 451, 476 (1960). 



2"- F. Arcamone, C. Bonino, E. B. Chain, A. Ferrettl, P. Pennella, 

 A. Tonola and Lidia Vero, Nature 187 238 (1960). 



^°^ M. Abe, S. Yamatodani, T. Yamano and M. Kusumoto, /. Agr. 

 Chem. Soc. Japan 34 249 (1960). 



^''^M. Abe and S. Yamatodani, Bull. Agr. Chem. Soc. (Japan) 19 

 161 (1955). 



