Pfizer Handbook of Microbial Metabolites 706 



930a Molliclavine, CieHjgOoNo, colorless crystals, m.p. 253° (dec), 

 [a]i>'' +30° (c 1.0 in pyridine). 



Claviceps purpurea 



An antibiotic of novel structure incorporating an indole 

 nucleus is: 



391b PA-155A, C14H15O2N3, colorless crystals, m.p. 209°, [ajp^^ -214° 

 (c 2.0 in methanol), U.V. 218, 273, 281, 288 m/x. 



No reaction with dinitrophenylhydrazine. Negative 

 ninhydrin, FeCl^ tests. Blue Ehrlich's test. Decolorizes 

 Br2, KMn04. Streptomyces alhus''^' "'^^ 



i. PYRIDINES 



The plant toxin, fusaric acid, was produced when 

 Fusarium oxysporum var. lini was grown on artificial 

 medium or on non-resistant flax tissues, but not when 

 the fungus was grown on resistant strain tissues. -°'^ 



A dissertation has been pubUshed on dipicolinic acid 

 formation and other chemical aspects of bacterial sporula- 

 tion.-"^ 



The mononucleotide of nicotinic acid has been isolated 

 from a fusarium specimen^°^ and from a yeast.-"* 



k. PYRAZINES, DIKETOPIPERAZINES 



Several diketopiperazines have been isolated from the 

 fungus Rosellinia necatrix Berlese.-"'' They are L-prolyl- 



^•'' Koppaka V. Rao, Antibiotics and Chemotherapy 10 312 (1960). 

 ''^" Manfred von Schach, private communication. 

 205 E. J. Trione, Phytopathologij 50 480 (1960). 

 2''« Herbert M. Nakata, Dissertation Abstr. 20 3020 (1960). 

 2"' A. Ballio and S. Russi, Arch. Biochem. and Biophys. 85 567 

 (1959). 



2'« R. W. Wheat, ibid. 85 567 (1957). 



2"»Yu-Shih Chen, Bull. Agr. Chem. Sac. (Japan) 24 372 (1960). 



