yog Addendum 



teniim crystalloiodimim Sasaki, Yoshida et Sasaki have 

 been identified as iodinin and 1,6-dihydroxyphenazine, 

 respectively.-^* 



m. PYRIMIDINES 



Two dissertations have been pubhshed on the bio- 

 synthesis of pyrimidines, one with rat Uver enzymes,^^' 

 the other with Neurospora crassa.'^^'^ 



Thymidine diphosphate mannose (as well as the pre- 

 viously reported thymidine diphosphate rhamnose) has 

 been isolated from cultures of Streptomyces griseus.^^'' 



It is possible that this substance is an intermediate in 

 the biosynthesis of streptomycin B (o(-T>-mannopyranosyl- 

 streptomycin) which is produced by this organism along 

 with streptomycin. 



Tritium labeling experiments indicated that in the 

 case cited, at least, the epimerization of N-acetylglu- 

 cosamine to N-acetylmannosamine, probably by way of 

 uridine diphosphate N-acetylglucosamine, does not in- 

 volve oxidation to a ketosugar, followed by stereospecific 

 reduction. -^^^ 



The structure of tubercidin, C11H14O4N4, m.p. 247'' 

 (dec), [alo^' —62°, produced by Streptomyces tubercidi- 

 cus and active against Mycobacterium tuberculosis and 

 Candida albicans, has been reported to be:-^**" 



NH2 



I 



4-amino-7-[D-ribofuranosyl]- 

 pyrrolo-[2,3-d]-pyrimidine 



^ 



-N-^ 



D-ribose 

 Toyocamycin has a similar structure. ^^^^ 



2^*Tosi Irle, Etsuro Kurosawa and Iwao Nagaoka, Bull. Chem. 

 Soc. Japan 33 1057 (1960). 



215 Richard L. Stambaugh, Dissertation Abstr. 20 64 (1959). 



2i6Kamala P. Chakraborty, ibid. 20 3044 (1960). 



21" J. Baddiley and N. L. Blumson, Biochim et Biophys. Acta 39 

 376 (1960). 



218 Luis Glaser, ibid. 41 534 (1960). 



218" Saburo Suzuki and Shingo Marumo, J. Antibiotics (Japan) 

 13A 360 (1960). 



218" Kazuhiko Ohkuma, ibid. 13A 361 (1960). 



