Pfizer Handbook of Microbial Metabolites 712 



corporated into pteridines, but not into purines produced 

 by the organism. ^^^ 



The structure of "active formaldehyde" (N^N^°-methyl- 

 enetetrahydrofolic acid) has been proved by synthesis. ^^* 



19. Unclassified Metabolites 



Streptolydigin probably contains 4 carbon-carbon dou- 

 ble bonds conjugated v\dth a ^-diketone system. -^'^ It also 

 contains at least four hydroxyl groups, at least four C- 

 methyl groups and at least one amide group. Methyla- 

 mine was a base hydrolysis product of tetradecahydro- 

 streptolydigin. 



Griseoviridin, empirical formula C22Ho9±207N3S, prob- 

 ably consists of three moieties. ^^'^ A 6 carbon atom frag- 

 ment has been identified as: 



and the sulfur atom may be attached at the X-position. 



The probable structure of a methanolysis product of 

 carzinophilin has been published. ^^^ It is: 



Methyl 1 -methyl- 7-methoxynaphthalene-6-carboxylate 



CH3 



CH3O 



CH3OOC 



Mikamycin should be classified as a polypeptide of the 

 etamycin type. L-Proline and glycine have been char- 

 acterized in a hydrolysate. A monoacetate, a di-2,4- 

 dinitrophenylhydrazone derivative, and a decahydro de- 



"3 O. Brenner-Holzbach and F. Leuthardt, Helv. Chim. Acta 42 

 2254 (1959). 



-•^* M. J. Osborn, P. T. Talbot and F. M. Huennekens, J. Am. Chem. 

 Soc. 82 4921 (1960). 



-^'^ Jerome Allen Course, Dissertation, Univ. of Illinois, 1959. 



236 p. de Mayo and A. Stoessl, Can. J. Chem. 38 950 (1960). 



237 Masao Tanaka, Teruo Kishi and Yoshiki Maruta, /. Antibiotics 

 (Japan) 12B 361 (1959). 



