THE GENETICS OF TUMOR TRANSPLANTATION 305 



work has been done in this field — with properly controlled material — that it 

 remains practically an open door for experimentation. 



Up to the establishment of the Mendelian nature of the genetic factors 

 influencing growth of transplants, Loeb had presented the only comprehen- 

 sive theory to attempt to explain success or failure of implants of normal 

 tissues. In 1924 Little (47) reviewed and criticized Loeb's work up to that 

 point. Discrepancies between experimental results and Loeb's theory 

 were pointed out. 



Later Loeb and Wright (56) and Loeb and King (55) investigated the 

 transplantation of normal tissues in inbred and hybrid strains of guinea 

 pigs and rats. The data obtained from these experiments were in agree- 

 ment with the genetic theory of transplantation of tumors as given earlier 

 in this chapter. 



So also were the results of Bittner (17) working with mice. 



We may, therefore, conclude that distinct advances in our knowledge 

 can be made when further studies along these lines have been conducted. 



Conclusion 



In conclusion we may point out the fact that few investigators as yet 

 recognize and utilize the great opportunities for new attacks on many basic 

 biological problems afforded by the recent advances in our knowledge of the 

 genetics of tissue transplantation. 



With inbred strains of mice now available there is a whole new field of 

 attack, not only on the problems of experimental cancer, but on those of 

 the nature of individuality and of the fundamental processes of ontogeny. 



BIBLIOGRAPHY 



1. Andervont, H. B. 1932. Studies on immunity induced by mouse sarcoma 180. 

 Pub. Health Rep., U.S.P.H.S. 47: 1859-77. 



2. Andervont, H.B. 1933. Specificity of immunity elicited by mouse sarcoma 180. 

 Pub. Health Rep., U.S.P.H.S. 48: 1472-76. 



3. Andervont, H. B. 1934. Use of pure strain animals in studies on resistance to 

 transplantable tumors. Pub. Health Rep., U.S.P.H.S. 49: 60-65. 



4. Andervont, H. B. 1937. Pulmonary tumors in mice. III. The serial trans- 

 mission of induced lung tumors. Pub. Health Rep., U.S.P.H.S. 52: 347-355. 



5. Andervont, H. B. 1937. Use of pure strain animals in studies on natural 

 resistance to transplantable tumors. Pub. Health Rep., U.S.P.H.S. 52: 1885- 

 1895. 



6. Barnes, W. A. and J. Furth. 1937. A transmissible leukemia in mice with 

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