ENDOCRINE SECRETION AND TUMOR FORMATION 315 



cration was secured with mouse sarcoma 180 and slight inhibition of growth 

 was observed with mouse sarcoma S3 7 (83). Tumor grafts grew more 

 slowly in hypophysectomized animals than in controls of the same age but 

 the relation of final tumor weight to body weight of operated and control 

 mice of equal age was the same (38). 



Gonadectomy and sex itself has been considered as a factor effecting 

 the growth of transplantable tumors. Both have been reported of some 

 influence with particular tumors (76, 77, 69, 85). 



The extracts of many internal secreting glands in addition to those 

 already mentioned have been used in attempts to alter the growth of 

 spontaneous and transplantable mouse tumors (64, 65, 2, 26, 67, 22, 62, 63). 

 The subject offers interesting possibilities. 



Hormone production with tumors. — An adenocarcinoma arising pre- 

 sumably from follicle tissue of the ovary has been tested and found to secrete 

 estrogenic hormone (78). Evidence of estrogenic activity was also seen in 

 one mouse with bilateral granulosal cell tumors (34). 



A lengthening and finally cessation of estrous cycles has been noted 

 following transplantation with tumors (60). With the growth of spon- 

 taneous mammar}' gland tumors estrous cycles became infrequent with long 

 continued periods of diestrus, and finally disappeared. Sections of the 

 genital organs showed them to be in extremely atrophic condition approach- 

 ing that of ovariectomized animals. Cycles were obtained by injection of 

 estrogen. The acyclic condition in tumor mice probably involves primarily 

 the gonadotropic function of the pituitary (i). 



BIBLIOGRAPHY 



1. Allen, E., A. W. Diddle, L. C. Strong, T. H. Burford and W. U. Gardner. 

 1935. Estrous cycles in mice during growth of spontaneous mammary tumors and 

 the effects of ovarian follicular and anterior pituitary hormones. Am. J. Cancer 

 25: 291. 



2. Arloing, p., a. Morel, A. Josserand and A. Badinand. 1933. Absence of 

 inhibiting agents for transplantable mouse cancer in adrenalin and certain of its 

 derivatives. Compt. rend. Soc. de biol. 114: 631. 



3. Bagg, H. J. 1936. Further studies on the relation of functional activity of 

 mammary carcinoma in mice. Am. J. Cancer 27: 542. 



4. Bagg, H. J. AND J. Jacksen. 1937. The value of a "functional test" in selecting 

 material for a genetic study of mammary tumors in mice and rats. Am. J. Cancer 



30: 539- 



5. BiscHOFF, F., L. C. Maxwell and M. L. Long. 1937. Urine of pregnancy and 

 tumor growth (sarcoma 180). Am. J. Cancer 31: 72. 



