Cnapter 12 



INFECTIOUS DISEASES OF MICE 



By John H. Dingle, Harvard Medical School. 



Introduction, 380. Bacterial disease, 381. Mouse typhoid, 381. Septicemic dis 

 eases of mice: pasteurellosis, pseudotuberculosis, mouse septicemia, 391. Diseases 

 due to infection with Streptohacillus and pleuropneumonia-like organisms — arthritis 

 of mice, 399. Epidemic pneumonia in mice, 409. Infectious catarrh of mice, 413. 

 Pyogenic infections, botriomycosis, 415. Infection with Bacillus piliformis, 416. 

 Infection due to Bartonella, Eperythrozoon and Grahamella, 419. Miscellaneous 

 bacterial infections, 429. Fungus diseases, 429. Spirochetosis and leptospirosis 

 in mice, 431. Spirillum minus, 4:3,1. Leptospira ictcrolicmorrhagiac, 4^^. Virus dis- 

 eases of mice, 434. Infectious ectromelia, 434. Lymphocytic choriomeningitis, 438. 

 Encephalomyelitis of mice (Theiler), 443. Virus pneumonia in mice, 448. Inclusion 

 bodies in the salivary glands and liver of the mouse, 451. Factors influencing the 

 production of experimental and natural disease in mice, 452. Prevention of dis- 

 ease and control of outbreaks, 455. Bibliography, 457. 



Introduction 



Mice have been employed experimentally since the early days of bacteri- 

 ology. Until fairly recently, however, there has been a lack of extensive 

 information regarding their anatomy and physiology, and considerable 

 confusion with respect to the nature, etiological agents, and pathology of 

 their infectious diseases. 



It is essential for any investigator who utilizes mice to become familiar 

 with the well animal. Anatomical descriptions are available in this book 

 and elsewhere (133, no), as well as reports concerning operative techniques 

 (133), induction of narcosis (133), the blood picture (201, 247), temperature 

 (247, 130), intestinal flora (307), and death rate (299) of normal mice, and 

 the effect of starvation on temperature, blood, etc. (130). 



Equally imperative is it that he be acquainted with the clinical signs and 

 pathological features of their spontaneous diseases. Such knowledge may 

 avoid embarrassing confusion by the recognition of a latent infection whose 

 manifestations might otherwise be misleading in the evaluation of experi- 

 mental data or in an attempt to isolate an etiological agent from other hosts. 

 Moreover, with early recognition of disease in valuable stock, such as genet- 



380 



