Contents 



Contributors to Volume I v 



Preface vii 



1. Introduction by J. N. Davidson and Erwin Chargaff 1 



I . The Early History 1 



II. The Two Types of Nucleic Acid 3 



III. Previous Literature 7 



2. Chemistry of Ribose and Deoxyribose by W. G. Overend and M. Stacey . . 9 



I . Introduction 9 



II. Occurrence of D-Ribose and 2-Deoxy-D-Ribose 11 



III. Chemistry of Ribose 16 



IV. Chemistry of 2-Deoxyribose 48 



V. Addendum 60 



Appendix 65 



3. Chemistry of Purines and Pyrimidines by Aaron Bendich 81 



I. Introduction 81 



II. General Properties of Purines and Pyrimidines 107 



III. Synthetic Methods 125 



Addendum 135 



General References 136 



4. Chemistry of Nucleosides and Nucleotides by J. Baddiley 137 



I. Nucleosides 138 



II. Nucleotides 160 



III. Addendum 188 



5. Hydrolysis of Nucleic Acids and Procedures for the Direct Estimation of 

 Purine and Pyrimidine Fractions by Absorption Spectrophotometry by 



Hubert S. Loring 191 



I. Hydrolysis of Nucleic Acids 191 



II. Estimation of Purine and Pyrimidine Components in PNA 199 



6. The Separation of Nucleic Acid Derivatives by Chromatography on Ion-Ex- 

 change Columns by Waldo E. Cohn 211 



I. Ion Exchange 212 



II. The Separation of Bases and Nucleosides 217 



III. Separation of Nucleotides 221 



IV. Separations Involving Sugar-Borate Complexing 235 



V. Related Reviews 241 



ix 



