136 AARON BENDICH 



tobacco mosaic virus in amounts equal to about 20 % of the normal uracil 

 content/*^ 



Exposure of neutral aqueous solutions of uric acid to ultraviolet irradia- 

 tion gives rise to triuret (1 ,3-dicarba,mylurea).''^" 



A detailed paper dealing with the occurrence of 5-hydroxymethylcytosine 

 in the DNA of bacteriophages T2 , T4 , and Te of E. coli has appeared.^" 

 The free synthetic base survives treatment with 72 % HCIO4 for one hour 

 at 100°, but such conditions lead to its destruction when in nucleic acid 

 linkage. 



A thoughtful review of the chemistry of the simple p> rimidines has re- 

 cently been written. ^^^ 



The presence of 2-methyladenine in the vitamin Bi2-like factor "A" and 

 in crystalline pseudovitamin Bi2d has been announced .^*^''*^* 



General References 



E. Fischer, "Unterschungen in der Puringruppe." Springer, Berlin, 1907. 



A. Fodor, in "Biochemisches Handlexikon" (Abderhalden, ed.), Vol. 9, p. 262. Springer, 



Berlin, 1915. 

 V. Meyer and P. Jacobson, "Lehrbuch der organischen Chemie," Vol. II, pp. 1172, 



1247. De Gruyter, Berlin and Leipzig, 1920. 

 S. J. Thannhauser, in "Biochemisches Handlexikon" (Abderhalden, ed.). Vol. 10, p. 



113. Springer, Berlin, 1923. 

 P. A. Levene and L. W. Bass, "Nucleic Acids." Chemical Catalog Co., New York, 1931. 

 T. B. Johnson and D. A. Hahn, P3friniidines : their amino and aminooxy derivatives, 



Chem.Revs. 13, 193 (1933). 



A. Winterstein and F. SomI6, Purine, pyrimidine und verwandte verbindungen, in 



"Handbuch der Pflanzenanalyse" (Klein, ed.), Vol. 4, p. 362. Springer, Vienna, 

 1933. 

 T. B. Johnson, The Chemistry of pyrimidines, purines, and nucleic acids, in "Organic 

 Chemistry, An Advanced Treatise" (Oilman, ed.). Vol. 2, p. 948. Wiley, New 

 York, 1938. 



B. Lythgoe, Some aspects of pj^rimidine and purine chemistry, Quart Revs. {London) 



3, 181 (1949). 

 H. Bredereck, Purin und pyrimidinverbindungen, in "Physiologische Chemie" (Flas- 



chentrager and Lehnartz, eds.), Vol. 1, p. 796. Springer, Berlin, 1951. 

 D. O. Jordan, Nucleic acids, purines and pyrimidines, Ann. Rev. Biochem. 21, 209 



(1952). 



^** R. Jeener and J. Rosseels, Biochim. et Biophys. Acta 11, 438 (1953). 



"« J. Fellig, Science 119, 129 (1953). 



«i G. R. Wyatt and S. S. Cohen, Biochem. J. 55, 774 (1953). 



«2 D. J. Brown, The Simple Pyrimidines, Rev. Pure Appl. Chem. 3, 115 (1953). 



*^3 F. B. Brown and E. L. Smith, Biochem. J., in press. 



«■» H. W. Dion, D. G. Calkins, and J. J. Pfiifner, /. Am. Chem. Sac. 76, 948 (1954), 



