178 



J. BADDILEY 



TABLE II 

 Properties of Nucleotides 



Nucleotide 



M.p., °C. 



Inosine-5' -phosphate 

 (muscle inosinic 

 acid) 



Adenosine-5' -phos- 

 phate (muscle ad- 

 enylic acid) 



Guanosine-5' -phos- 

 phate 



Cytidine-5' -phos- 

 phate 



Uridine-5' -phosphate 



Adenylic acid a 



Adenylic acid b 



Cytidylic acid a 



Cytidylic acid b 

 Uridylic acid a 

 Uridylic acid b 



Thymidine -5'-phos- 

 phate 



Cytosine deoxyribo- 

 side-5'-phosphate 



Thymidine-3', 5' -di- 

 phosphate 



Cytosine deoxyribo- 

 side-3', 5' -diphos- 

 phate 



192 



190-200 

 (dec.) 

 233 



197 (dec.) 



238-240 



(dec.) 



233-234 



183-187 



Derivatives 



— 18.5° (2.5% forms crystalline ammonium, 

 HCl) barium, calcium, sodium, and 



potassium salts 

 -46.4° (H2O) acridine salt, m.p. 208° 

 -47.5° 

 (NaOH) 



dibrucine salt, m.p. 210-220° 

 (dec. with prelim, softening) 

 27.1° (H2O) dibrucine salt, softens 185°, m.p. 

 215° (dec.) 

 barium salt, hexagonal plates; 

 dibrucine salt, softens 185° 

 molten at 202°, needles [a] „ 

 — 70.4° (pyridine) 

 187 (dec.) -84.3° (form- dibrucine salt, m.p. 165-175° 

 amide) 

 58.7° (form- 

 amide) 

 20.7° (H2O) free nucleotide polymorphous 



49.0° (H2O) free nucleotide polymorphous 



lo -58.9° 



-4.4' 



14.4° (Ba 

 salt) 



dibrucine salt, [a] 



(pyridine) 

 dibrucine salt, rosettes of 



needles, softening at 140°, 



m.p. about 175° 



tetrabrucine salt, softens at 

 176°, m.p. 182-184° 



tetrabrucine salt, needles sinter- 

 ing at 180°, m.p. 185° 



and remarkable versatility of the nucleotide coenzymes warrants their 

 inclusion in this book. Although the chemical transformations which they 

 catalyze are of fundamental importance in all living cells, they are so numer- 

 ous and intimately interrelated that it is not possible to consider them here 

 and the following sections will be devoted entirely to their chemistry. It 

 will be seen that a common feature of the adenosine and uridine coenzymes 

 is the presence in the molecule of a pyrophosphate linkage. 



