CONTENTS 



CHAP. PAGE 



I. Introduction i 

 II. Aneurine (Thiamine) 



1. Historical g 



2. Isolation of Aneurine lo 



3. Chemical Constitution of Aneurine 12 



4. Synthesis of Aneurine 15 



5. Properties of Aneurine 22 



6. Stability of Aneurine 23 



7. Biological Estimation of Aneurine 28 



8. Microbiological Assay of Aneurine 32 



9. Chemical Estimation of Aneurine 37 

 10. Occurrence of Aneurine in Foodstuffs 43 



II. Effect of Aneurine Deficiency in Animals 46 



12. Effect of Aneurine Deficiency in Man 56 



13. Effect of Excessive Dosage with Aneurine 62 



14. Metabolism of Aneurine 63 



15. Intestinal Synthesis of Aneurine 74 



16. Animal and Human Requirements of Aneurine 81 



17. Pharmacological Action of Aneurine 85 



18. Function of Aneurine 90 



19. Aneurine in the Nutrition of Micro-organisms 105 



20. Effect of Aneurine on Higher Plants 113 



21. Aneurine Requirements of Insects 115 



22. Analogues of Aneurine 116 



III. Riboflavine 



1. Introduction 132 



2. Isolation of Riboflavine 134 



3. Chemical Constitution of Riboflavine 135 



4. Synthesis of Riboflavine 140 



5. Microbiological Production of Riboflavine 148 



6. Properties of Riboflavine • 154 



7. Estimation of Riboflavine 156 



8. Occurrence of Riboflavine inToodstuffs 164 



9. Effect of Riboflavine Deficiency in Animals 168 



10. Effect of Riboflavine Deficiency in Man 173 



11. Metabolism of Riboflavine 177 



12. Intestinal Synthesis of Riboflavine 183 



13. Animal and Human Requirements of Riboflavine 186 



14. Pharmacological Action of Riboflavine 190 



15. Function of Riboflavine 190 



16. Riboflavine in the Nutrition of Micro-organisms 203 



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