CONTENTS 



CHAP. 



17. Effect of Riboflavine on Higher Plants 205 



18. Riboflavine Requirements of Insects 205 



19. Analogues of Riboflavine 206 



IV. Nicotinic Acid (Niacin) 



1. Introduction 211 



2. Isolation of Nicotinic Acid 214 



3. Preparation of Nicotinic Acid 214 



4. Properties of Nicotinic Acid 217 



5. Estimation of Nicotinic Acid 218 



6. Occurrence of Nicotinic Acid in Foodstuffs 232 



7. Effect of Nicotinic Acid Deficiency in Animals 237 



8. Effect of Nicotinic Acid Deficiency in Man 240 



9. Biosynthesis of Nicotinic Acid 249 



10. Metabolism of Nicotinic Acid 252 



1 1 . Intestinal Synthesis of Nicotinic Acid 268 



12. Animal and Human Requirements of Nicotinic Acid 272 



13. Pharmacological Action of Nicotinic Acid 273 



14. Function of Nicotinic Acid 274 



15. Nicotinic Acid in the Nutrition of Micro-organisms . 281 



16. Effect of Nicotinic Acid on Higher Plants 286 



17. Nicotinic Acid Requirements of Insects 287 



18. Analogues of Nicotinic Acid 288 



V. Pyridoxine (Adermin: Vitamin Bg) 



1. Historical 296 



2. Isolation of Pyridoxine 298 



3. Chemical Constitution of Pyridoxine 298 



4. Synthesis of Pyridoxine 301 



5. Properties of Pyridoxine 307 



6. Stability of Vitamin Bg 308 



7. Estimation of Vitamin Bg 309 



8. Occurrence of Vitamin Bg in Foodstuffs 315 



9. Effect of Vitamin Bg Deficiency in Animals 317 



10. Effect of Vitamin Bg Deficiency in Man 322 



11. Metabolism of Pyridoxine 325 



12. Intestinal Synthesis of Vitamin Bg 327 



13. Animal and Human Requirements of Pyridoxine 328 



14. Pharmacology of Pyridoxine 329 



15. Function of Pyridoxine and Related Compounds 330 



16. Pyridoxine in the Nutrition of Micro-organisms 338 



17. Effect of Pyridoxine on Higher Plants 341 



18. Pyridoxine Requirements of Insects 341 



19. Analogues of Pyridoxine 342 



VI. Pantothenic Acid 



1. Historical 348 



2. Isolation of Pantothenic Acid 351 



viii 



