CONTENTS 



CHAP. PAGE 



3. Chemical Constitution and Synthesis of Pantothenic Acid 352 



4. Properties of Pantothenic Acid 359 



5. StabiHty of Pantothenic Acid 359 



6. Estimation of Pantothenic Acid 360 



7. Occurrence of Pantothenic Acid in Foodstuffs 363 



8. Effect of Pantothenic Acid Deficiency in Animals 365 



9. Effect of Pantothenic Acid Deficiency in Man 372 



10. Metabolism of Pantothenic Acid 373 



11. Intestinal Synthesis of Pantothenic Acid 376 



12. Human and Animal Requirements of Pantothenic Acid 377 



13. Pharmacology of Pantothenic Acid 379 



14. Pantothenic Acid in the Nutrition of Micro-organisms 380 



15. Effect of Pantothenic Acid on Higher Plants 389 



16. Pantothenic Acid Requirements of Insects 389 



17. Function of Pantothenic Acid 390 



18. Pantothenic Acid Analogues 394 



VII. BlOTIN 



1. Introduction 404 



2. Isolation of Biotin 406 



3. Chemical Constitution of Biotin 407 



4. Synthesis of Biotin 414 



5. Properties of Biotin 420 



6. Stability of Biotin 421 



7. Estimation of Biotin 421 



8. Occurrence of Biotin in Foodstuffs 423 



9. Effect of Biotin Deficiency in Animals 424 



10. Effect of Biotin Deficiency in Man 432 



11. Metabolism of Biotin 433 



12. Intestinal Synthesis of Biotin 434 



13. Animal and Human Requirements of Biotin 436 



14. Pharmacology of Biotin 437 



15. Biotin in the Nutrition of Micro-organisms 438 



16. Effect of Biotin on Plants 44 ^ 



17. Biotin Requirements of Insects 441 



18. Function of Biotin 442 



19. Analogues of Biotin . 446 



VIII. The Folic Acid Complex 



1. Introduction 457 



2. Isolation of Folic Acid 466 



3. Chemical Constitution of Folic Acid 471 



4. Synthesis of Folic Acid 474 



5. Properties of Folic Acid 477 



6. Stability of Folic Acid 479 



7. Estimation of Folic Acid 4^^ 



8. Occurrence of Folic Acid Complex 483 



9. Effect of Folic Acid Deficiency in Animals 484 



ix 



