STABILITY 



pH values, 3' * but is more sensitive to changes of pH.^^ Between 3-5 

 and 7'0, the increase in sensitivity is proportional to the logarithm of 

 the velocity coefficient for the destruction of cocarboxylase minus the 

 logarithm of the coefficient for the destruction of aneurine at any 

 given pR. The rate of thermal destruction, like that of aneurine, is 

 higher the greater the initial concentration.®" 



References to Section 6 



1. D. Melnick, W. D. Robinson and H. Field, /. Biol. Chem., 1941, 



138, 49. 



2. K. T. H. Farrer, /. Proc. Austral. Chem. Inst., 1941, 8, 113. 



3. B. W. Beadle, D. A. Greenwood and H. R. Kraybill, /. Biol. 



Chem., 1943, 149, 339, 349- 



4. R. G. Booth, Biochem. J., 1943, 37, 518. 



5. K. Myrback, I. Vallin and B. Kihlberg, Svensk Kem. Tidskr., 1942, 



54, 97- 



6. K. T. H. Farrer, Biochem. J., I945» 39. 128. 



7. K. T. H. Farrer, ibid., 1947, 41, 162. 



8. K. T. H. Farrer, ibid., 167. 



8a. K. T. H. Farrer, Brit. J. Nutr., 1948, 2, 242. 



9. F. C. Mclntire and D. V. Frost, /. Amer. Chem. Soc, 1944, 66, 1317. 



10. E. H. Spitzer, A. I. Coombus, C. A. Elvehjem and W. Wisnicky, 



Proc. Soc. Exp. Biol. Med., 1941, 48, 376. 



11. C. A. Evans, W. E. Carlson and R. G. Green, Amer. J. Path., 1942, 



18, 79 ; R. G. Green, W. E. Carlson and C. A. Evans, /. Nutrition, 

 1942, 23, 165 ; R. R. Sealock, A. H. Livermore and C. A. Evans, 

 /. Amer. Chem. Soc, 1943, 65, 935. 



12. P. S. Owen and J. W. Ferrebee, New England J. Med., 1946, 162, 



267. 



13. R. R. Sealock and R. L. Goodland, /. Amer. Chem. Soc, 1944, 



66, 507. 



14. A. H. Livermore and R. R. Sealock, /. Biol. Chem., i947» 167, 699. 

 14a. R. R. Sealock and A. H. Livermore, ibid., 1949, 177, 553 ; R. R. 



Sealock and N. C. Davis, ibid., 987. 



15. D. C. Smith and L. M. Prout, Proc. Soc. Exp. Biol. Med., 1944, 



56, I. 



16. D. Melnick, M. Hochberg and B. L. Oser, /. Nutrition, 1945, 30, 



81. 



17. L. O. Krampitz and D. W. Woolley, /. Biol. Chem., 1944, 152, 9- 



18. R. R. Sealock and A. H. Livermore, ibid., 1944, 166, 379. 



19. K. Bhagvat and P. Devi, Indian J. Med. Res., 1944. 32, 123, 131. 



139. 



20. K. P. Jacobsohn and M. D. Azevedo, Arch. Biochem., 1947, 14, 83. 



21. P. H. Weswig, A. M. Freed and J. R. Haag, /. Biol. Chem., 1946, 



165, 737. 

 2ia. B. Thomas and H. F. Walker, /. Soc. Chem. Ind., 1949, 68, 6. 



22. K. T. H. Farrer, Biochem. J., 1945, 39, 261. 



27 



