EFFECT OF DEFICIENCY IN MAN 



Aneurine and Cancer 



J. E. Ayre and W. A. G. Bauld ^^ noted that abnormal oestrogenic 

 activity in cases of menorrhagia and uterine cancer was often associ- 

 ated with a vitamin B^ deficiency, though not with a deficiency of 

 other vitamins. They therefore suggested that aneiu-ine deficiency 

 over a prolonged period may pre-dispose either to menorrhagia or to 

 malignancy. It is suggested that the finding of a vitamin B^ de- 

 ficiency together with an abnormally high level of oestrogen may be 

 indicative of a dangerous pre-cancerous state. 



References to Section 12 



1. T. Lee, Chinese Med. /., 1940, 58, 314. 



2. G. R. Minot, M. B. Strauss and S. Cobb, New Engcand J. Med., 



1933, 208, 1244 .* N. Jolliffe and P. M. JofEe, Proc. Soc. Exp. 

 Biol. Med., 1935, 32, 1161 ; N. Jolliffe, C. N. Colbert and P. M. 

 Joffe, Amer. J. Med. Sci., 1936, 191, 515. 



3. E. D. Plass and W. F. Meugert, /. Amer. Med. Assoc, 1933, 101, 



2020 ; M. R. Strauss and W. J. Macdonald, ibid., 1933, 100, 

 1320. 



4. R. E. Hibbs, Ann. Int. Med., 1946, 25, 270. 



5. H. M. Sinclair, Proc. Roy. Soc. Med., 1939, 32, 807. 



6. R. Goodhart and H. M. Sinclair, /. Biol. Chem., 1940, 132, 11. 



7. K. A. Smith and H. L. Mason, Proc. Staff Meetings Mayo Clinic, 



1940. 15, 529. 



8. W. Needles, /. Amer. Med. Assoc, 1943, 121, 914. 



9. R. Kapeller-Adler and J. A. Cartwright, Edinburgh Med. J., 1943, 



50, 305. 

 ID. H. E. de Wardener and B. Lennox, Lancet, 1947, 1, 11. 



11. N. Jolliffe, R. Goodhart, J. Gennis and J. K. CUne, Amer. J. Med. 



Sci., 1939, 198, 198. 



12. K. O. Elsom, F. D. W. Lukens, W. H. Montgomery and L. Jonas, 



/. Clin. Invest., 1940, 19, 153. 



13. R. D. Williams, H. L. Mason and B. F. Smith, Proc. Staff Meetings 



Mayo Clinic, 1939, 14, 787 ; R. D. Wilhams, H. L. Mason, 

 R. M. Wilder and B. F. Smith, Arch, intern. Med., 1940, 66, 

 785 ; R. D. Williams, H. L. Mason, B. F. Smith and R. M. 

 Wilder, ibid., 1942, 69, 721 ; R. D. Williams, H. L. Mason, 

 M. H. Power and R. M. Wilder, ibid., 1943, 71, 38. 



14. R. D. Wilhams and E. C. Kendall, ibid., 1943, 72, 185. 



15. R. H. Williams, E. Egana, P. Robinson, S, P. Asher and C. Dutoit, 



ibid., 1943, 72, 353. 



16. M. K. Horwitt, E. Liebert, O. Kreisler and P. Wittman, Science, 



1946, 104, 407. 



17. A. Keys, A. F. Hcnschel, H. L. Taylor, O. Mickelsen and J. Brozek, 



Amer. J. Physiol., 1945, 144, 5. 



18. J. E. Ayre and W. A. G. Bauld, Science, 1946, 103, 441. 



61 



