ANIMAL AND HUMAN REQUIREMENTS 



15. B. Alexander and G. Landwehr, Science, 1945, 101, 229. 



16. F. M. Meyers, Amer. J. Med. Sci., 1941, 201, 785, 



17. A. Williamson and H. T. Parsons, /. Nutrition, 1945, 29, 51. 



18. J. G. Reinhold, J. T. L. Nicholson and K. O'S. Elsom, ibid., 1944, 



28, 51. 



19. B. S. Schweigert, J. M. Mclntire, L. M. Henderson and C. A. 



Elvehjem, Arch. Biochem., 1945, 6, 403. 



20. H. T. Parsons, A. Williamson and M. L. Johnson, /. Nutrition, 



1945. 29, 373. 



21. H, T. Parsons, A. Foeste and H. Gilberg, ibid., 383. 



22. R. C. Thompson, Univ. Texas Publ., 1942, No. 4237, p. 87. 



23. P. R. Burkholder and I. McVeigh, Proc. Nat. Acad. Sci., 1942, 28. 



285. 



24. M. I. Wegner, A. N. Booth, C. A. Elvehjem and E. B. Hart, Proc. 



Soc. Exp. Biol. Med., 1940, 45, 769. 



25. C. H. Hunt, C. H. Kirk, E. W. Burroughs, R. M. Bethke, A. F. 



Schalk and P. Gerlaugh, /. Nutrition, 1941, 21, 85. 



26. L. W. McElroy and H. Goss, /. Biol. Chem., 1939, 130, 437 ; /. 



Nutrition, 1941, 21, 163. 



27. C. H. Hunt, E. W. Burroughs, R. M. Bethke, A. F. Schalk and 



P. Gerlaugh, ibid., 1943, 25, 207. 



16. ANIMAL AND HUMAN REQUIREMENTS OF ANEURINE 



It is clear that from what has been said in the preceding section on 

 bacterial synthesis in the intestine that animal and human require- 

 ments for aneurine may well be affected — possibly to a very consider- 

 able degree — by the incidence of this phenomenon. Unfortunately, 

 no precise information is available at present to indicate how common 

 intestinal synthesis is in man or in other animals, or to what extent 

 the aneurine thus provided is available to meet the requirements of 

 the host. 



One can only suspect, from the fact that it was discovered com- 

 paratively recently, that intestinal synthesis is an infrequent and 

 circumscribed source of aneurine, and that the values arrived at for 

 human requirements before the phenomenon came to light still remain 

 generally valid, although possibly wide of the mark in exceptional 

 instances. This supposition is believed not to hold good with some 

 other members of the vitamin B complex. 



The first attempts to determine the amounts of aneurine needed 

 by an animal were carried out by T. B. Osborne and L. B. Mendel,^ 

 who showed that the amount required increased with the weight of 

 the animal. This was confirmed by G. R. Cowgill,^ who studied the 

 aneurine requirements of four different species of animals and obtained 

 the following results : 



6 81 



