PHARMACOLOGICAL ACTION 



3. C. A. Mills, Proc. Soc. Exp. Biol. Med., 1943, 54, 265. 



4. A. Z. Baker and M. D. Wright, Proc. Roy. Soc. Med., 1936, 29, 



II45- 



5. A. G. van Veen, Geneesh. Tijdschr. Nederl.-Ind., 1935, 75, 2050. 



6. W. Stepp, J. Kuhnau and H. Schroeder, Die Vitamine, Stuttgart, 



F. Enhe, 1937. 



7. M. G. Vorhaus, R. R. Williams and R. E. Waterman, /. Amer. 



Med. Assoc, 1935, 105, 1580. 



8. K. O'S. Elsom, J. G. Reinhold, J. T. L. Nicholson and C. Chornock, 



Amer. J. Med. Sci., 1942, 203, 569. 



9. D. Melnick, /. Nutrition, 1942, 24, 139. 



10. R. D. Williams, H. L, Mason and R. M. Wilder, ibid., 1943, 25, 



71- 



11. H. Oldham, F. Johnston, S. Kleiger and H. H. Arismendi, ibid., 



1944, 27, 435. 



12. T. Moran and R. G. Booth, Chem. and Ind., 1940, 533. 



13. M. D. Wright, ibid., 578. 



14. E. G. Young, Canadian Med. Assoc. J., 1945. 53, 527. 



15. R. L. Lane, E. Johnson and R. R. Williams, /. Nutrition, 1942, 



23, 613. 



16. E. M. Knott, Proc. Soc. Exp. Biol. Med., 1940, 45, 765 ; E. M. 



Knott, S. C. Kleiger, F. W. Schultz and G. Collins, /. Pediat., 

 1943, 22, 43 ; L. E. Holt, R. L. Nemir, S. E. Snyderman, A. A. 

 Albanese, K. C. Ketron, L. P. Guy and R. Carreters, /. 

 Nutrition, 1949, 37, 53. 



17. B. Alexander, G. Landwehr and F. Mitchell, /. Clin. Invest., 1946, 



25, 287. 



18. M. L. Hathaway and J. E. Strom, /. Nutrition, 1946, 32, i. 



19. H. G. Oldham, M. V. Davis and L. J. Roberts, ibid., 163. 



20. Food Consumption Levels in the United Kingdom, Cmd. 7203, 



H.M.S.O. 1947. 



21. J. C. Drummond, " Nutritional Requirements of Man in the Light 



of Wartime Experience ", Royal Institute of Chemistry, 1948. 



17. PHARMACOLOGICAL ACTION OF ANEURINE 

 Toxicity 



The acute fatal doses of aneurine hydrochloride for the mouse, rat, 

 rabbit and dog were found to be i» ^ 125, 250, 300 and 350 mg. per kg. 

 respectively by the intravenous route, and six and forty times these 

 values when given subcutaneously and orally. Death occurred from 

 respiratory failure. G. Hecht and H. Weese,^ however, reported that 

 160 mg. per kg. caused the death of rabbits by paralysis of the central 

 nervous system, whilst T. J. Haley and A. M. Flesher * found that the 

 lethal dose for rabbits was 126 mg. per kg. but, after a sensitising dose 

 of 100 mg. of aneurine hydrochloride, this increased to 238 mg. per 



85 



