PHARMACOLOGICAL ACTION 



was unaffected. In such animals the effects of acetyl choline would 

 presumably be prolonged. C. Torda and H. G. Wolff,^^ on the other 

 hand, failed to observe any inhibitory or potentiating effect of aneurine 

 hydrochloride, aneurine pyrophosphate or acetyl aneurine on the 

 response of frog's rectus muscle to acetyl choline. Aneurine hydro- 

 chloride and pyrophosphate increased acetyl choline synthesis by 

 about 10 % in concentrations of 3 x lo-^M and 2 X 10-^ M respec- 

 tively. Higher concentrations decreased the synthesis of acetyl 

 choline, whilst adrenaline increased the synthesis 40 to 150 %. 



E. M. Boyd and R. W. Dingwall "^ reported that concentrations of 

 100 to 250 mg. per 100 ml. prevented bradycardia in the exposed frog's 

 heart due to acetyl choline and other drugs. 



B. Jackson and G. Wald ® found that aneurine in dilutions of i in 

 1000 to 100,000 progressively antagonised acetyl choline ; the effect 

 was not shown by cocarboxylase. 



References to Section 17 



1. H. Molitor and W. L. Sampson, E. Merck's Jahresber., 1936, 50, 51. 



2. V. Erspamer, Arch. int. Pharmacodyn., 1940, 64, i. 



3. G. Hecht and H. Weese, Klin. Woch., 1937, 16, 414. 



4. T. J. Haley and A. M. Flesher, Science, 1946, 104, 567. 



5. E. L. Stern, Amer. J. Surg., 1938, 39, 495. 



5a. T. J. Haley, Proc. Soc. Exp. Biol. Med., 1948, 68, 153. 



6. C. Mano, Japan. J. Med. Sci., IV, 1940, 12, Proc, 98. 



7. E. M. Boyd and R. W. Dingwall, Quart. J. Pharm., 1941, 14, 209. 



8. B. Jackson and G. Wald, Amer. J. Physiol., 1942, 136, 464. 



9. K. Unna and E. P. Pick, /. Pharmacol., 1944, 81, 294. 



10. N. W. Shock and W. H. Sebrell, Amer. J. Physiol., 1944, 142, 265 ; 



Proc. Soc. Exp. Biol. Med., 1945, 69, 212. ' 



11. A. Liechti, A. von Muralt and M. Reinert, Helv. Physiol. Pharm. 



Acta, 1943, 1, 79. 



12. A. ajid F. Wyss, Experientia, 1945, 1, 160. 



13. A. von Muralt and F. Wyss, ibid., 1944, 2, 445. 



14. A. von Muralt, Nature, 1944, 164, 767. 



15. H. Haimovici and E. P. Pick, Proc. Soc. Exp. Biol. Med., 1946, 62, 



234- 



16. S. Loewe, I. Loewe and R. Knox, Amer. J. Digest. Dis., 1943, 10, 65. 

 i6a. J. A. Smith, P. P. Foa, H. R. Weinstein, A. S. Ludwig and J. M. 



Wertheim, /. Pharmacol., 1948, 93, 294. 



17. M. V. Dias, Science, 1947, 105> ^^i- 



18. R. Kuhn, T. Wieland and H. Huenschmann, Z. physiol. Chem., 



1939, 269, 48. 



19. D. Glick and W. Antopol, /. Pharmacol., 1939, 65, 389. 



20. V. Erspamer, Boll. Soc. ital. Biol, sperim., 1939, 14, 655 ; Arch. 



int. Pharmacodyn., 1939, 63, 385. 



21. E. A. Zeller and H. Birkhauser, Helv. Chim. Acta, 1940, 23, 1457. 



22. C. Torda and H. G. Wolff, Proc. Soc. Exp. Biol. Med., 1944, 66, 88, 89. 



89 



