ANEURINE (thiamine) 



aneurine, and it was therefore suggested that the thiazole half was 

 synthesised from the above four amino acids. 



Other Micro-organisms. Aneurine is essential for the growth of 

 the following flagellates : Polytoma ocellatum,'^^ P. caudatum,^'' and 

 Chilomonas paramaecium,^'^ which utilise the thiazole half in place of 

 aneurine ; Polytomella caeca,^^> *^ which requires either the intact 

 molecule or both halves ; Strigomonas oncopelti,^^ S. fasciculata ^° and 

 5. culicidarum,^^ all three of which require the intact aneurine molecule ; 

 Chlamydomonas orbicularis,^'^ Chlorogonium tetragamum ^^ and Haema- 

 tococcus pluvialis.^^ The ciliate, Glaucoma piriformis, required the 

 intact aneurine molecule and failed to respond to a mixture of the 

 thiazole and pyrimidine halves. ^^ 



References to Section 19 



1. E. Wildiers, La Cellule, 1901, 18, 313. 



2. W. Lash Miller, Trans. Roy. Soc, Canada, III, 1937, 31, 169. 



3. P. R. Burkholder, Amer. J. Bot., 1943, 30, 206. 



4. P. R. Burkholder and D. Moyer, Bull. Torrey Bot. Club, 1943, 70, 



372. 



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40, 426. 



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8. C. Marchant, Canad. J. Res., 1942, 20B, 21. 



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76. 



10. E. N. Odintzova, Compt. rend. Acad. Sci., U.R.S.S., 1943, 41, 250. 



11. H. Fink and F. Just, Biochem. Z., 1941, 308, 15 ; 1941, 309, i, 



212, 219 ; 1941-2, 311, 61, 287 ; 1942, 313, 39 ; Ber., 1942, 

 75B, 2101. 



12. J. M. van Lanen, H. P. Broquist, M. J. Johnson, I. L. Baldwin 



and W. H. Peterson, Ind. Eng. Chem., 1942, 34, 1244. 



13. E. Sperber and S. Renvall, Biochem. Z., 1941, 310, 160 ; E. Sperber, 



ibid., 1942, 313, 62. 



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15. W. H. Schopfer, Experientia, 1945, 1, i. 



16. W. H. Schopfer and A. Jung, Compt. rend., 1937, 204, 1500 ; 



H. M. Sinclair, Nature, 1937, 140, 360 ; W. J. Robbins and F. 

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17. W. J. Robbins, Bull. Torrey Bot. Club, 1938, 65, 267. 



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19. F. Kavanagh, Bull. Torrey Bot. Club, 1942, 69, 669. 



20. L. E. Hawker, Ann. Bot., 1944. 8, 79- 



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112 



