ANEURINE (thiamine) 



The anti-aneurine properties of these three compounds probably 

 depend on the fact that they bear a close structural similarity to 

 aneurine, and are thereby able to attach themselves to that portion 

 of the apoenzyme surface normally occupied by the aneurine molecule. 

 The antagonist-apoenzyme complex so formed is, however, incapable 

 of effecting the chemical changes characteristic of the aneurine- 

 apoenzyme complex, and pyruvic acid decarboxylation, for example, 

 therefore ceases, and the organism — whether bacteria or animal — 

 suffers in consequence from vitamin B^ deficiency and cannot develop 

 normally. 



References to Section 22 



1. A. R. Todd, F. Bergel and Karimullah, /. Chem. Soc, 1936, 1559. 



2. A. R. Todd and F. Bergel, ihid., 1937, ^5^A- 



3. H. Andersag and K. Westphal, Ber., 1937, 70, 2035. 



4. F. Schultz, Z. physiol. Chem., 1940, 265, 113. 



5. B. C. J. G. Knight and H. Mcllwain, Biochem. J., 1938, 32, 1241. 



6. P. Baumgarten, A. Dornow, K. Gutschmidt and H. Krehl, Ber., 



1942, 75, 442. 



7. M. Javillier and L. Emerique-Blum, Compt. rend., 1940, 211, 374. 



8. W. H. Schopfer, Helv, Physiol. Pharm. Acta, 1943, 1, 83. 



9. S. W. Fox, H. Sargent and E. R. Buchman, /. Amer. Chem. Soc, 



1945, 67, 496. 



10. E. and R. Abderhalden, Pflugers Archiv., 1938, 240, 746. 



11. S. Morii, /. Oriental Med., 1941, 55, 9 ; Biochem. Z., 1941, 309, 



354- 



12. D. Price and F. D. Pickel, /. Amer. Chem. Soc, 1941, 63, 1067. 



13. G. A. Stein, W. L. Sampson, J. K. Cline and J. R. Stevens, ibid., 



2059. 



14. F. Schultz, Z. physiol. Chem., 1941, 272, 29. 



15. W. H. Schopfer, Arch. Sci. phys. nat., 1941, [V], 23, Suppl., 58. 



16. W. Huber, /. Amer. Chem. Soc, 1943, 65, 2222. 



17. E. R. Buchman and E. M. Richardson, ihid., 1945, 67, 395. 



18. G. A. Emerson and P. L. Southwick, /. Biol. Chem., 1945, 160, 169. 



19. C. C. Price, N. J. Leonard and R. H. Reitsema, /. Amer. Chem. 



Soc, 1946, 68, 766. 



20. J. Finkelstein and R. C. Elderfield, /. Org. Chem., 1939, 4, 365. 



21. P. Baumgarten and A. Dornow, Ber., 1940, 73, 44, 156. 



22. P. Baumgarten and A. Dornow, ibid., 353. 



23. A. H. Tracy and R. C. Elderfield, Science, 1940, 92, 180 ; /. Org. 



Chem., 1941, 6, 54. 



24. F. C. Smelkes, Science, 1939, 90, 113 ; /. Amer. Chem. Soc, 1939. 



61, 2562. 



25. W. J. Robbins, Proc Nat. Acad. Sci., 1941, 27, 419. 



25a. A. N. Wilson and S. A. Harris, /. Amer. Chem. Soc, 1949, 71, 

 2231. 



26. W. H. Schopfer, Arch. Sci. phys. nat., 1941, [V], 23, Suppl., 64. 



130 



