EFFECT OF DEFICIENCY IN MAN 



19. W. Bolton, /. Agric. Sci., 1944, 34, 198. 



20. J. C. Fritz, W. Archer and D. Barker, Poultry Sci., 1939, 18, 449. 



21. T. H. Jukes, E. L. R. Stokstad and M. Belt, /. Nutrition, 1947, 



33, I. 



22. C. H. Hunt, A. R. Winter and R. M. Bethke, Poultry Sci., 1939, 



18, 330 ; A. E. Schumacher and G. F. Heuser, ibid., 369 ; A. L. 

 Romanoff and J, C. Bauernfeind, Anat. Rec, 1942, 82, n. 



23. B. A. McLaren, E. F. Herman and C. A. Elvehjem, Arch. Biochem., 



1946, 10, 453 ; B. A. McLaren, E. Keller, D. J. O'Donnell and 

 C. A. Elvehjem, ibid., 1947, 15, 169. 



24. M, A. Pollack, A. Taylor, J. Taylor and R. J. Williams, Cancer 



Res., 1942, 2, 739. 



25. H. P. Morris and W. van B. Robertson, /. Nat. Cancer Inst., 



1943. 3, 479. 

 25a. H. C. Stoerk and G. A. Emerson, Proc. Soc. Exp. Biol. Med., 

 1949, 70, 703. 



26. A. C. Grif&n and C. A. Baumann, Arch. Biochem., 1946, 11, 467. 

 26a. C. J. Kensler, /. Biol. Chem., 1949, 179, 1079. 



27. J. G. Wooley and W. H. Sebrell, U.S. Publ. Health Rep., 1942, 57, 



149. 



28. I. J. Kligler K. Guggenheim and E. Buechler, Proc. Soc. Exp, 



Biol. Med., 1944, 57, 132. 



29. A. F. Rasmussen, H. A. Waisman and H. C. Lichstein, ibid., 92. 



30. A. O. Seeler and W. H. Ott, /. Infect. Dis., 1944, 75, 175. 



31. J. Y. C. Watt, /. Hygiene, 1944, 39, 145. 



10. EFFECT OF RIBOFLAVINE DEFICIENCY IN 2V1AN 



The results of riboflavine deficiency in man conform to the general 

 pattern observed with experimental animals, and the most character- 

 istic symptoms are eye lesions and skin lesions. There is, however, 

 no unanimity amongst clinical workers as to wlich of the several 

 individual lesions are due to the absence of riboflavine or of other 

 memibers of the vitamin B complex. Indeed the clinical manifesta- 

 tions of riboflavine deficiency are less clearly defined than those 

 associated with a deficiency of aneurine or of nicotinic acid, and appear 

 to overlap to some extent with other deficiency symptoms, particularly 

 with those of nicotinic acid deficiency. 



Whilst it is possible that a pure riboflavine deficiency, uncompli- 

 cated by other vitamin deficiencies, may exist, it is more probable 

 that it generally occurs as part of a multiple vitamin B deficiency, 

 which can only be treated successfully with a mixture of factors, 

 including riboflavine. Thus, for example, Vilter et al.'^ obtained 

 beneficial effects by treatment with riboflavine of pellagrins whose 

 skin lesions had been cured by nicotinic acid but who still had vague 

 s5miptoms of ill-health. 



^7Z 



