INTESTINAL SYNTHESIS 



14. V. A. Najjar and L. E. Holt, Johns Hopkins Hosp. Bull., 1941, 



69, 479. 



15. A. Keys, A. F. Henschel, O. Mickelsen, J. Brozek and J. H. 



Crawford, /. Nutrition, 1944, 27, 165. 



16. R. D. Williams, H. L. Mason, P. L. Cusick and R. M. Wilder, 



ibid., 1943, 25, 361. 



17. A. E. Axelrod, T. D. Spies, C. A. Elvehjem and V. Axelrod, /. 



Clin. Invest., 1941, 20, 229. 



18. V. H. Feder, G. T. Lewis and H. S. Alden, J. Nutrition, 1944, 27, 



347- 



19. H. Oldham, F. Johnston, S. C. Kleiger and H. H. Arismendi, ibid., 



435- 



20. D. R. Hagedom, E. D. Kyhos, O. A. Germek and E. L. Sevringhaus, 



ibid., 1945, 29, 179. 



21. M. L. Hathaway and D. E. Lobb, ibid., 1946, 32, 9. 



22. B. Sure and Z. W. Ford, Endocrin., 1943, 32, 433. 



23. D. M. Tennant and R. H. Silber, /. Biol. Chem., 1943, 148, 359. 



24. G. C. Supplee, O. G. Jensen, R. C. Bender and O. J. Kahlenberg, 



ibid., 1942, 144, 79. 



25. W. H. Riesen, B. S. Schweigert and C. A. Elvehjem, Arch. Biochem., 



1946, 10, 387- 



26. A. Z. Murray, L. M. Greenstein and H. C. Sherman, /. Biol. Chem., 



1946, 165, 91- 



27. H. Selye, /. Nutrition, 1943, 25, 137. 



28. B. Sure and Z. W. Ford, ibid., 1943, 26, 659. 



29. V. Dubrauszky and S. Blazso, Z. Vitaminforsch., 1943, 14, 2, 13. 



30. W. Neuweiler and Esterman, ibid., 1946, 18, 74. 

 30a. J. Sos, Z. Vit. Horm. Ferment/., 1947, 1, 369. 



31. C. E. Roderuck, M. N. Coryell, H. H. WiUiams and I. G. Macy, 



Amer. J. Dis. Child., 1945, 70, 171 ; /.Nutrition, 1946, 32, 267. 



32. L. Randoin and A. RaSy, Bull. acad. me'd., 1943, 127, 12 ; Compt. 



rend. Soc. Biol., 1942, 136, 743. 



12. INTESTINAL SYNTHESIS OF RIBOFLAVINE 



Normal rats were reported ^ to excrete 55-6 fig. of riboflavine 

 daily in the faeces, compared with 24-6 /ig. in the urine. Adrenalec- 

 tomised rats excreted somewhat more by both routes. However, it is 

 generally agreed that the values obtained for faecal riboflavine excre- 

 tion cannot be used to assess nutritional status as they are determined 

 solely by the extent of intestinal synthesis and not by the dietary 

 intake. Thus, the amount of riboflavine excreted in the faeces was 

 approximately the same with an intake of 0, 10 and 40 /xg. per day. 2' ^ 



The nature of the diet affected the amount of riboflavine synthe- 

 sised in the gut, and rats excreted larger amounts in the faeces on diets 

 rich in dextrin or maize starch than on diets containing sucrose, 



183 



