INTRODUCTION 



C. Funk ^^ and from rice bran by Suzuki et al}"^ during attempts to 

 isolate the anti-beriberi factor. They observed that it had no bene- 

 ficial effect in beriberi, and did not apparently suspect that they had 

 actually isolated a vitamin capable of curing a different deficiency 

 disease. 



Nicotinic acid is known in the U.S.A. as niacin, this name having 

 been coined to make the distinction between the vitamin and the 

 alkaloid, nicotine, quite clear to the lay public. 



References to Section i 



1. J. Goldberger, G. A. Wheeler and V. P. Sydenstricker, /. Amer. 



Med. Assoc, 1918, 71, 944. 



2. J. Goldberger and W. F. Tanner, U.S. Pub. Health Rep., 1925, 40, 58. 



3. J. Goldberger and R. D. Lillie, ibid., 1926, 41, 201. 



4. P. Gyorg}^ Nature, 1934, 133, 498. 



5. C. A. Elvehjem and C. J. Koehn, /. Biol. Chem., 1935, 108, 709. 



6. C. A. Elvehjem and C. J. Koehn, /. Nutrition, 1936, 11, 67. 



7. J. Goldberger, G. A. Wheeler, R. D. Lillie and L. M. Rogers, 



U.S. Publ. Health Rep., 1926, 41, 297 ; J. Goldberger and G. A. 

 Wheeler, ibid., 1927, 42, 1299, 2383 ; 1929, 44, 2769 ; G. A. 

 Wheeler, ibid., 1931, 46, 2663 ; 1933, 48, 67 ; G. A. Wheeler 

 and D. J. Hunt, ibid., 1933, 48, 754 ; 1934, 49, 732 ; 1926, 41, 

 201. 



8. J. Goldberger and G. A. Wheeler, ibid., 1928, 43, 172 ; J. Gold- 



berger, G. A. Wheeler, R. D. Lillie and L. M. Rogers, ibid., 1928, 

 43, 657, 1385 ; J. Goldberger, G. A. Wheeler, L. M. Rogers and 

 W. H. Sebrell, ibid., 1930, 45, 273, 1297 ; W. H. Sebrell, G. A. 

 Wheeler and D. J. Hunt, ibid., 1935, 50, 1333 ; G. A. Wheeler 

 and W. H. Sebrell, U.S. Nat. Inst., Health Bull, 1933, 162. 



9. J. Goldberger and W. F. Tanner, U.S. Publ. Health Rep., 1925, 



40, 54. 



10. C. A. Elvehjem, R. J. Madden. F. M. Strong and D. W. Woolley, 



/. Amer. Chem. Soc, 1937, 59» i7^7- 



11. H. R. Street and G. R. Cowgill, Proc. Soc. Exp. Biol. Med., 1937, 



37, 547. 



12. H. Chick, T. F. Macrae, A. J. P. Martin and C. J. Martin, Biochem. 



J., 1938, 32, 10. 



13. T. D. Spies, C. Cooper and M. A. Blankenhom, /. Amer. Med. 



Assoc, 1938, 110, 622 ; T. D. Spies, Lancet, 1938, 1, 252. 



14. L. J. Harris, Chem. and Ind., 1937, 56, 1134. 



15. D. T. Smith, J. M. Ruffin and S. G. Smith, /. Amer. Med. Assoc, 



1937. 109, 2054. 



16. C. Funk, /. State Med., 1912, 20, 341 ; /. Physiol., 1913, 46, 173 ; 



Brit. Med. J., 1913, 1, 814. 



17. U. Suzuki and S. Matsunaga, /. Agr. Tokyo Imp. Univ., 1912, 5, 



59 ; U. Suzuki, T. Shamimura and S. Okade, Biochem. Z., 1912, 

 43, 89, 99. 



213 



