PROPERTIES 



10. H. Weidel and K. Hazura, Monatsh., 1882, 3, 783. 



11. Z. H. Skraup and A. Cobenzl, ibid., 1883, 4, 458. 



12. Z. H. Skraup and G. Vortmann, ibid., 594. 



13. Reilly Tar & Chemical Corp., B.P. 561722, 561723. 



14. Reilly Tar & Chemical Corp., B.P. 563273. 



15. Pittsburgh Coke & Iron Co., B.P. 570427. 



16. Reilly Tar & Chemical Corp., B.P. 563274. 



17. Allied Chemical & Dye Corp., U.S. P. 2436660. 



18. Reilly Tar & Chemical Corp., B.P. 568889. 



19. A. Zimmerli, U.S. P. 2394650. 



20. C. F. Woodward, C. O. Badgett and J. G. Kaufman, Ind. Eng. 



Chem., 1944, 36, 544. 



21. O. Fischer, Bar., 1882, 15, 63. 



22. S. M. McElvain and M. A. Goese, /. Amer. Chem. Soc, 1941, 63, 



2283. 



23. C. Engler, Ber., 1894, 27, 1787 ; F. Pollak, Monatsh., 1895, 16, 53. 



24. F. B. LaForge, /. Amer. Chem. Soc, 1928, 50, 2477. 



25. S. Keimatsu, K. Yokata and I. Satoda, /. Pharm. Soc, Japan, 



1933. 53, 994- 



26. P. W. Garbo, U.S.P. 2427400. 



27. Ciba Ltd., B.P. 558774. 



28. Ciba Ltd., B.P. 561019. 



29. P. W. Garbo, U.S.P. 2419831. 



30. Geigy Colour Co. Ltd., I. E. Balaban and F. Manchester, B.P. 



575119. 



31. Pyridium Corp., B.P. 563184. 



31a. A. Galat, /. Amer. Chem. Soc, 1948, 70, 3945- 



32. J. R. Bovamick, /. Biol. Chem., 1943, 149, 301 ; I943» 151, 467 ; 



1944, 153, I. 



4. PROPERTIES OF NICOTINIC ACID 

 Nicotinic Acid 



Nicotinic acid forms white needles, m.p, 235-5 to 236-5° C. It is 

 sparingly soluble in cold water, but soluble in hot water and alcohol ; 

 it is sparingly soluble in ether. It sublimes without decomposition 

 on heating. It behaves as a base, forming a crystalline hydrochloride, 

 m.p. 274° C, and other salts, and also as an acid, forming salts with 

 metals, and esters with alcohol. The methyl ester is a solid, m.p. 

 38° C, and the ethyl ester a liquid, b.p. 223 to 224° C. Nicotinic acid 

 forms an acid chloride, amide, hydrazide, etc. 



Nicotinic acid sold in Great Britain for pharmaceutical purposes 

 must conform to certain standards laid down in the Fourth Addendum 

 to the British Pharmacopoeia, 1932, and modified in the 1948 edition. 

 Nicotinic acid tablets were included in the Seventh Addendum. The 

 dosage is now given as 15 to 30 mg. daily for prophylaxis, and 50 to 

 250 mg. daily for therapeutic use and the substance is normally 

 dispensed in 50-mg. tablets. 



217 



