NICOTINIC ACID (nIACIN) 



2. S. A. Singal, V. P. Sydenstricker and J. M. Littlejohn, /. Biol. 



Chem., 1948, 176, 1051, 1063. 



3. V. A. Najjar, L. E. Holt, G. A. Johns, G. C. Medairy and G. Fleisch- 



mann, Proc. Soc. Exp. Biol. Med., 1946, 61, 371 ; H. P. Sarett 

 and G. A. Goldsmith, /. Biol. Chem., 1949, 177, 461 ; R. W. 

 Vilter, J. F. Mueller and W. B. Bean, /. Lab. Clin. Med., 1949, 

 34, 409. 



4. S. E. Snyderman, K. C. Ketron, R. Carretero and L. E. Holt, 



Proc. Soc. Exp. Biol. Med., 1949, 70, 569. 



5. J. M. Hundley, ibid., 592. 



6. L. M. Henderson and L. V. Hankes, ibid., 26. 



7. W. W. Hurt, B. T. Scheer and H. J. Deuel, Arch. Biochem., 1949, 



21, 37. 



8. B. S. Schweigert and P. B. Pearson, /. Biol. Chem., 1947, 168, 



^^=, ; G. H. Bell, B. T. Scheer and H. J. Deuel, /. Nutrition, 



1948, 35, 239. 



9. C. Heidelberger, M. E. Gullberg, A. F. Morgan and S. Lepkovsky, 



/. Biol. Chem., 1948, 175, 471 ; C. Heidelberger, E. P. Abraham 

 and S. Lepkovsky, ibid., 1949, 176, 1461 ; C. Heidelberger, ibid., 



1949, 179, 139 ; C. Heidelberger, M. E. Gullberg, A. F. Morgan 

 and S. Lepkovsky, ibid., 143 ; C. Heidelberger, E. P. Abraham 

 and S. Lepkovsky, ibid., 151. 



10. J. M. Hundley and H. W. Bond, Arch. Biochem., 1949, 21, 



313. 



11. H. K. Mitchell, J. F. Nye and R. D. Owen, /. Biol. Chem., 1948, 



175, 433 ; P. W. Albert, B. T. Scheer and H. J. Deuel, ibid., 



479. 



12. B. S. Schweigert, ibid., 1949, 178, 707 ; B. S. Schweigert and M. M. 



Marquette, ibid., 1949, 181, i99- 



13. L. M. Henderson, ibid., 1949, 178, 1005. 



14. R. E. Kalho and C. P. Berg, ibid., 1949, 181, 333. 



15. P. Ellinger and M. M. Abdel Kader, Nature, 1947. 160, 675 ; 1949, 



163, 799 ; Biochem. J., 1949, 44, 285, 506 ; 1949, 45, 276. 



16. W. I. M. Holman and D. J. de Lange, Nature, 1950, 165, ii2. 



10. METABOLISM OF NICOTINIC ACID 

 Fate of Ingested Nicotinic Acid and Nicotinamide 



The earliest attempts to study the fate of nicotinic acid in the 

 body were confined to the estimation of the urinary excretion of free 

 nicotinic acid and its amide. Normal subjects were said to excrete 

 up to 30 mg. per day,^» ^ whereas in pellagrins the amount excreted 

 was extremely low.^ 



It was soon recognised, however, that ingested nicotinic acid was 

 excreted in other foiTQs, and the first derivatives of nicotinic acid to 

 be recognised as metabolites were nicotinuric acid and trigonelline. 



252 



