PROPERTIES 



References to Section 4 



1. S. A. Harris and K. Folkers, /. Amer. Chem. Soc, 1939, 61, 1245, 



3307. 



2. E. J. Reedman, W. L. Sampson and K. Unna, Proc. Soc. Exp. 



Biol. Med., 1940, 43, 112. 



3. R. Kuhn, K. Westphal, G. Wendt and G. Westphal, Naturwiss., 



1939. 27, 469. 



4. A. Ichiba and K. Michi, Sci. Papers Inst. Phys. Chem. Res. [Tokyo], 



1939, 36, 173. 



5. S. Gabriel and J. Colman, Ber., 1900, 33, 988. 



6. S. Morii and K. Makino, Enzywologia, 1939, 7, 385. 



7. Merck & Co., U.S.P. 2399347. 



8. Merck & Co., B.P. 534916-7 ; U.S.P. 2422616. 



9. Merck & Co., B.P. 543615 ; U.S.P. 2422617, 2422622. 



10. Merck & Co., B.P. 557804 ; U.S.P. 2422619. 



11. Merck & Co., B.P. 557805 ; U.S.P. 2422618, 2422620. 



12. Merck & Co., B.P. 536249. 



13. Merck & Co., U.S.P. 2422621. 



14. Merck & Co., B.P. 603442. 



15. Hoffmann-La Roche, B.P. 550889. 



16. Hoffmann-La Roche, B.P. 550939. 



17. Hoffmann-La Roche, B.P. 552419. 



18. Hoffmann-La Roche, B.P. 556044. 



19. Hoffmann-La Roche, B.P. 556136; U.S.P. 2410938-41. 



20. Hoffmann-La Roche, B.P. 570365. 



21. Hoffmann-La Roche, B.P. 552808. 



22. Hoffmann-La Roche, B.P. 553097. 



22a. Roche Products Ltd., B.P. 625997, 629450. 



23. Lederle Inc., B.P. 56761 1 ; American Cyanamid Co., B.P. 626368. 



5. PROPERTIES OF PYRmOXINE 



The first compound with vitamin Bg-activity to be isolated in the 

 pure state was 3-hydroxy-4 : 5-bis-hydroxymethyl-2-methyl-pyridine 



HOf JJCH2OH 



3V "~ 



CH3I j^ 



for which the name adermin was proposed by R. Kuhn, and pyridoxine 

 by P. Gyorgy and R. E. Eckardt.^ The latter name is to be preferred, 

 for Gyorgy and Eckardt showed that crystalline vitamin Bg hydro- 

 chloride, unlike the crude concentrates with which the early results 

 had been obtained, generally failed to cure rat acrodynia and, in the 



307 



