EFFECT OF DEFICIENCY IN ANIMALS 



that pyridoxine-deficients rats, immunised against sheep red cells, 

 had much lower agglutinin and haemolysin titres than normal controls 

 and controls of equal bodyweight caused by underfeeding. Pyridoxine 

 had no effect, however, on the susceptibility of Swiss mice to experi- 

 mental poliomyelitis.^^ 



Pyridoxine and Cancer 



The implantation of Flexner-Jobling carcinoma in rats partially 

 depleted of vitamin Bg resulted in fewer " takes " than in normal rats, 

 the number of regressions were higher and the tiunours were smaller.^^ 

 Similar results were obtained with Yale carcinoma and fibrosarcoma, 

 whilst the production of tumours by painting with methylcholanthrene 

 was retarded in animals fed a vitamin Bg-deficient diet. Vitamin 

 Bg deficiency had less effect, however, on the production of sarcomas 

 by subcutaneous injection of methylcholanthrene. 



References to Section 9 



1. W. Antopol and K. Unna, Proc. Soc. Exp. Biol. Med., 1939, 42, 



126; Arch. Path., 1942, 33, 241. 



2. P. J. Fouts, O. M. Helmer and S. Lepkovsky, Proc. Soc. Exp. 



Biol. Med., 1939, 40, 4. 



3. H. J. Borson and R. S. Mettier, ibid., 1940, 43, 429. 



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1941, 21, 275. 



5. J. M. McKibbin, A. E. Schaefer, D. V. Frost and C. A. Elvehjem. 



/. Biol. Chem., 1942, 142, 77. 



6. T. H. Jukes, Proc. Soc. Exp. Biol. Med., 1939, 42, 180. 



7. S. Lepkovsky and F. H. Kratzer, /. Nutrition, 1942, 24, 515. 



8. H. Chick, T. F. Macrae and A. N. Worden, Biochem. J., 1940, 34, 



580 ; H. Chick, M. M. El Sadr and A. N. Worden, ibid., 1940, 

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1942, 95, 331. 



9. F. H. Bird, F. H. Kratzer, V. S. Asmundson and S. Lepkovsky, 



Proc. Soc. Exp. Biol. Med., 1943, 62, 44. 



10. D. M. Hegsted and M. N. Rao, /. Nutrition, 1945, 30, 367. 



11. A. Romberg, H. Tabor and W. H. Sebrell, Amer. J. Physiol., 



1945. 143, 434. 

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15. Le R. Voris and H. P. Moore, ibid., 1943, 25, 7. 

 21 321 



