PYRIDOXINE 



due to arsenic ; the simultaneous administration of pyridoxine and 

 tocopherol was said to give the best results. Some improvement was 

 also reported by C. L, Miller ^ in cases of postencephalitic and idio- 

 pathic paralysis agitans after treatment with pyridoxine, but in 

 neither condition was there a return to normal. It had no beneficial 

 effect in epilepsy. ^^ 



iVliscellaneous 



One of the few conditions in which pyridoxine has been successfully 

 employed is in the treatment of nausea. Complete or considerable 

 relief was obtained in nausea and vomiting of pregnancy,^^ using a 

 dose of 10 to 20 mg. three or four times daily, and in radiation sickness 

 or nausea following exposure to X-rays ; ^^ this was checked by 

 single or repeated intravenous injection of 25 mg. of pyridoxine at 

 twenty-four to seventy- two-hourly intervals. 



Pyridoxine has been claimed to be of value in certain forms of 

 dermatitis, for example, in cheilosis ^^ and in post-adolescent acne 

 vulgaris.^* 



Pyridoxine was claimed to be effective in agranulocytic angina,^^ 

 and was said to increase the white cell count and granulocytes in 

 patients with toxic granulocytopenia. It was suggested that pyri- 

 doxine might be the factor involved in the maturation of the poly- 

 morphonuclear leucocytes and the stimulation of granulocytopoiesis. 

 Intravenous injections cf pyridoxine (200 mg. per day) caused a rapid 

 increase in the leucocytes of patients who developed granulocytopenia 

 as the result of treatment with thiouracil.^^ 



References to Section 10 



1. W. W. Hawkins and J. Barsky, Science, 1948, 108, 284. 



la. T. D. Spies, W. B. Bean and W. F. Ashe, /. Amer. Med. Assoc, 

 1939. 112, 2414. 



2. R. W. Vilter, H. S. Schiro and T. D. Spies. Nature, 1940, 145, 388. 



3. R. Kark, E. L. Lozner and A. P. Meiklejohn, Proc. Sac. Exp. Biol. 



Med., 1940, 43, 97. 



4. W. Antopol and C. E. Schotland, /. Amer. Med. Assoc, 1940, 114, 



1058. 



5. H. M. Keith, /. Pediat., 1942, 20, 200. 



6. E. E. Rosenbaum, S. Portis and S. Soskin, /. Lab. Clin. Med., 



1942, 27, 763. 



7. A. B. Baker, /. Amer. Med. Assoc, 1941, 116, 2484. 



8. R. W. Vilter. C. D. Aring and T. D. Spies, ibid., 1940, 116, 209. 



9. C. L. Miller, Minnesota Med., 1942, 25, 22. 



10. J. T. Fox and G. M. TuUidge, Lancet, 1946, 2, 343. 



11. H. B. Weinstein, Z. Wohl. G. J. Mitchell and G. F. Sustendal. 



Amer. J. Obstet. Gynec, 1944, 47, 389. 



324 



