PANTOTHENIC ACID 



9. N. Nielsen, V. Hartelius and V. Schmidt, Naturwiss., 1943, 31, 



550. 



10. R. H. Silber, /. Nutrition, 1944, 27, 425. 



11. E. E. Rice, E. J. Strandine, E. M. Squires and B. Lyddon, Arch. 



Biochem., 1946, 10, 251. 



12. A. Taylor, M. A. Pollack, M. J. Hofer and R. J. Williams, Cancer 



Res., 1942, 2, 752. 



13. M. N. Coryell, M. E. Harris, S. Miller, H, H. Williams and I. G. 



Macy, Amer. J. Dis. Child., 1945, 70, 150. 



14. H. Spector, T. S. Hamilton and H. H. Mitchell, /. Biol. Chem., 



1945. 161. 145- 



15. L. D. Wright and E. Q. Wright, Proc. Soc. Exp. Biol. Med., 1942, 



49, 80. 



16. D. M. Tennant and R. H. Silber, /. Biol. Chem., 1943, 148, 359. 



17. R. H. Silber, Arch. Biochem., 1945, 7, 329. 



18. C. E. Meyer, I. F. Burton and C. E. Sturgis, Proc. Soc. Exp. Biol. 



Med., 1942, 49, 363. 



19. B. Lustig, A. R. Goldfarb and B. Gerstl, Arch. Biochem., 1944, 6, 



59- 



20. M. M. Nelson, F. van Nonhuys and H. M. Evans, /. Nutrition, 



1947, 34, 189. 



21. H. P. Sarett, /. Biol. Chem., 1945, 159, 321. 



II. INTESTINAL SYNTHESIS OF PANTOTHENIC ACID 



Evidence for the synthesis of pantothenic acid by micro-organisms 

 in the rumen of ruminants was presented by L. W. McElroy and 

 H. Goss,^ who observed that the dried contents of the rumen and the 

 reticulum of sheep and cows maintained on a diet low in the vitamin 

 B complex contained respectively twenty-five and twenty- to thirty- 

 fold the amount of pantothenic acid present in the diet, whilst milk 

 from these cows contained twice the amount of pantothenic acid 

 ingested in the diet, another illustration of the possible importance of 

 this phenomenon in human nutrition. 



Only indirect evidence is available to indicate that pantothenic 

 acid is synthesised in the intestines of animals. Thus pantothenic 

 acid deficiency was induced in experimental animals by the feeding 

 of sulphonamides,2» ^ which presumably inhibited the development of 

 the intestinal flora. L. D. Wright and A. D. Welch ^ found that 

 administration of succinylsulphathiazole not only caused severe 

 symptoms of pantothenic acid deficiency, but considerably reduced 

 the pantothenic acid content of the liver ; the storage of riboflavine 

 and nicotinic acid on the other hand was unaffected, whilst that of 

 biotin and folic acid was increased. Neither the symptoms of panto- 

 thenic acid deficiency nor the low level in the liver was affected by 



376 



