EFFECT OF DEFICIENCY IN MAN 



53. T. J. Cunha, L. K. Bustad, W. E. Ham, D. R. Cordy, E. C. 



McCuUoch, L. F. Woods, G. H. Conner and M. A. McGregor, 



/. Nutrition, 1947, 34, 173. 

 53a. T. J. Cunha, R. W. Colby, L. K. Bustad and J. F. Bone, ibid.. 



1948, 36, 215. 

 536. G. E. Cartwright, J. Fay, B, Tatting and M. M. Wintrobe, /. Lah. 



Clin. Med., 1948, 33, 397. 



54. W. C. Langston, W. J. Darby, C. P. Shukers and P. L. Day, /. 



Exp. Med., 1938, 68, 923. 



55. P. L. Day, V. Mims, J. R. Totter, E. L. R. Stokstad, B. L.Hutchings 



and N. H. Sloane, /. Biol. Chem., 1945, 157, 423. 



56. J. R. Totter, Ann. N. Y. Acad. Sci., 1946, 48, 309. 



57. J, M. Cooperman, K. B. McCall and C. A. Elvehjem, Science, 1945, 



102, 645 ; J. M, Cooperman, H. A. Waisman, K. B. McCall and 

 C. A. Elvehjem, /. Nutrition, 1945, 30, 45 ; J. M. Cooperman, 

 C. A. Elvehjem, K. B. McCall and W. R. Ruegamer, Proc. Soc. 

 Exp. Biol. Med., 1946, 61, 92. 



58. J. M. Cooperman, W. R. Ruegamer, E. E. Snell and C. A. Elvehjem, 



/, Biol. Chem., 1946, 163, 769. 



59. R. Hertz, Proc. Soc. Exp. Biol. Med., 1948, 67, 113. 



60. B. A. McLaren, E. Keller, D. J. O'Donnell and C. A. Elvehjem, 



Arch. Biochem., 1947, 15, 169. 



61. H. C. Lichstein, K. B. McCall, C. A. Elvehjem and P. F. Clark, 



/. Bad., 1946, 52, 105. 



62. W. K. Summers, Proc. Soc. Exp. Biol. Med., 1947, 66, 509. 



63. H. R. Morgan, ibid., 1948, 67, 29. 



64. C. Leuchtenberger, R. Lewisohn, D. Laszlo and R. Leuchtenberger, 



ibid., 1944, 55, 204. 



65. R. Leuchtenberger, C. Leuchtenberger, D. Laszlo and R. Lewisohn, 



Science, 1945, 101, 16 ; R. Lewisohn, C. Leuchtenberger, R. 

 Leuchtenberger and J. C. Keresztesy, ibid., 1946, 104, 436. 



66. A. D. Bass and M. L. H. Freeman, Proc. Soc. Exp. Biol. Med., 



1947' 66, 523. 



10. EFFECT OF FOLIC ACID DEFICIENCY IN MAN 



Folic Acid in the Treatment of Anaemia and Related Conditions 



The first account of the effect of folic acid in human anaemia was 

 given by T. D. Spies and his colleagues,' » 2 y^\^Q showed that the syn- 

 thetic crystalline L. casei factor produced a sharp reticulocyte response 

 in patients with nutritional macrocytic anaemia in relapse, followed 

 by a rise in the red blood cells and haemoglobin. What was at the 

 time particularly surprising was that an equally good response was 

 obtained whether the preparation was given parenterally or by 

 mouth. Later it was reported ^ that a number of cases of pernicious 



495 



