METABOLISM 



31C. J. L. Ternberg and R. E. Eakin, /. Amer. Chem. Soc, 1949, 71, 



3858. 

 31^. L. M. Meyer, N. D. Ritz, A. Cuccese, J. Rutzky, A. Sawitsky and 

 G. Bock, Amer. J. Med. Sci., 1949, 218, 197. 



32. E. E. Hays, Proc. Soc. Exp. Biol. Med., 1946. 62, 558. 



33. P. L. Day. V. Mims, J. R. Totter, E. L. R. Stokstad, B. L. 



Hutchings and N, H. Sloane, /. Biol. Chem., 1945, 167, 423. 



34. F. S. Daft and W. H. Sebrell, U.S. Publ. Health Rep., 1943, 58, 



1542. 



35. T. H. Jukes and E. L. R. Stokstad, /. Biol. Chem., 1947, 168, 



563. 



36. R. M. Suarez, A. D. Welch, R. W. Heinle, R. M. Suarez, jni. and 



E. M. Nelson, /. Lab. Clin. Med., 1946, 31, 1294. 



37. T. D. Spies, Southern Med. J., 1946, 39, 634 ; T. D. Spies and 



R. E. Stone, ibid., 1947, 40, 46 ; T. D. Spies, G. G. Lopez, F. 

 Milanes and T. Aramburu, /. Amer. Med. Assoc, 1947, 134, 

 18. 



38. D. A. K. Black and S. W. Stanbury, Lancet, 1947, 1, 827. 



39. H. M. Denny, M. L. Menten and E. Graff, Amer. J. M^ed. Sci., 



1946, 211, 672. 

 Sga. J. H. Waelsch, Lancet, 1948, 2, 888. 



40. C. J. Watson, W. H. Sebrell, J. L. McKelvey and F. S. Daft, 



Amer. J. Med. Sci., 1945, 210, 463. 



41. C. A. Doan, ibid., 1946, 212, 257. 



41a. S. P. Stearnes, Proc. Soc. Exp. Biol. Med., 1948, 69, 518. 



42. S. Farber, E. C. Cutler, J. W. Hawkins, J. H. Harrison, E. C. 



Peirce and G. G. Lenz, Science, 1947, 106, 619 ; L. M. Meyer, 

 Trans. N.Y. Acad Sci., 1948, 10, 99 I M. J. Kleiner, ibid., 71 ; 

 S. P. Lehr, L. T. Wright, S. Weintraub and I. Arons, ibid., 75. 



43. D. Slaughter, Science, 1949, 109, 286. 



II. METABOLISM OF FOLIC ACID 



According to Steinkamp et al.^ normal subjects excreted in the 

 urine 2 to 4 /xg. per day of pteroylglutamic acid, as estimated micro- 

 biologically with S. faecalis R. Following oral administration of a 

 test-dose, 15 to 75 %, with an average of 28-5 %, was recovered in 

 the urine. 



The amount excreted increased with the amount administered, 

 being as much as 50 % with a 5 mg. oral dose ; nearly all was ex- 

 creted within six hours. 1°' ^^ The di- and tri-glutamate, but not the 

 heptaglutamate, were converted into pteroylglutamic acid.^'' Monkeys 

 reacted differently and the addition to a folic acid-deficient diet of 

 various forms of pteroylglutamic acid failed to increase the urinary or 

 faecal excretion appreciably ; the former only amounted to about 

 I % and the latter to much less than i % of a i mg. dose.^* 



503 



