INOSITOL 



Slow growth and a normocytic anaemia were produced in turkey 

 poults by a deficiency of inositol. ^^ 



Inositol deficiency in young rainbow trout resulted in degeneration 

 of the fins and in distended stomachs. ^^ The symptoms were pre- 

 vented by 25 to 50 mg. per 100 g. of diet. 



Effect on Infected Animals 



Inositol had no effect on the susceptibility of Swiss mice to experi- 

 mental poliomyelitis. 25 



Inositol and Cancer 



The inositol content of transplanted epidermal carcinoma in mice 

 was more than twice that of normal epidermis, but methyl cholanthrene- 

 treated epidermis contained only the normal amount. 2 « 



Inositol inhibited the growth of transplanted tumours in mice 

 when given intravenously.^' Its effect on transplanted sarcoma in 

 mice was counteracted by ^-aminobenzoic acid and other compounds. ^^ 



References to Section 7 



1. D. W. WooUey, Science, 1940, 92, 384 ; /. Biol. Chem., 1940, 136, 



113 ; 1 94 1, 139, 29 ; /. Nutrition, 1941, 21, Suppl. 17. 



2. D. W. Woolley, Proc. Soc. Exp. Biol. Med., 1941, 46, 565 ; /. Exp. 



Med., 1942, 75, 277. 



3. G. J. Martin, M. R. Thompson and J. de Carvajal-Forero, Amer. J. 



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4. P. I.. Pavcek and H. M. Baum, Science, 1941, 93, 502. 



5. W. Halliday and H. M. Evans, /. Nutrition, 1937, 14, 45. 



6. T. J. Cunha, S. Kirkwood, P. H. PhilHps and G. Bohstedt, Proc. 



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10. G. Gavin, J. M. Patterson and E. W. McHenry, ibid., 1943, 148, 



275. 



11. J. C. Forbes, Proc. Soc. Exp. Biol. Med., 1943, 54, 89. 



12. J. M. R. Beveridge and C. C. Lucas, /. Biol. Chem., 1945, 157, 311. 



13. C. H. Best, C. C. Lucas, J. M. Patterson and J. H. Ridout, Science, 



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15. A. G. Hogan and J. W. Hamilton, ibid., 1942, 23, 533. 



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Exp. Biol. Med., 1943, 52, 250. 



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574 



