HUMAN AND ANIMAL REQUIREMENTS 



1 8. D. M. Hegsted. G. M. Briggs, R. C. Mills. C. A. Elvehjem and E. B. 



Hart, Proc. Soc. Exp. Biol. Med., 1941, 47, 376. 



19. H. Dam, /. Nutrition, 1944, 27, 193. 



20. G. J. Martin, M. R. Thompson and J. de Carvajal-Forero, Amer. J. 



Digest. Dis., 1942, 9, 268. 



21. D. C. Lindley and T. J. Cunha, /. Nutrition, 1946, 32, 47. 



22. T. J. Cunha, L. K. Bustad, W. E. Ham, D. R. Cordy, E. C. 



McCuUoch, L. F. Woods, G. H. Conner and M. A. McGregor, 

 ibid., 1947, 34, 173. 



23. T. H. Jukes, E. L. R. Stokstad and M. Belt, ibid., 1947, 33, i. 



24. B. A. McLaren, E. Keller, D. J. O'Donnell and C. A. Elvehjem, 



Arch. Biochem., 1947, 15, 169. 



25. H. C. Lichstein, H. A. Waisman, K. B. McCall, C. A. Elvehjem 



and P. F. Clark, Proc. Soc. Exp. Biol. Med., 1945, 60, 279. 



26. E. L. Tatum, M. G. Ritchey, E. V. Cowdry and L. F. Wicks, /. 



Biol. Chem., 1946, 163, 675 ; M. G. Ritchey, L. F. Wicks and 

 E. L. Tatum, ibid., 1947, l"?!* 5i- 



27. D. Laszlo and C. Leuchtenberger, Science, 1943, 97, 515. 



28. J. C. Keresztesy, D. Laszlo and C. Leuchtenberger, Cancer Res., 



1946, 6, 128. 



8. EFFECT OF INOSITOL DEFICIENCY IN 2VIAN 



Administration of inositol to patients with gastro-intestinal cancer 

 reduced the characteristic fatty infiltration of the liver,^ and it has 

 been suggested ^ that the lipotropic action of inositol may be of value 

 in the treatment of psoriasis. It has been stated ^ that a compound 

 of a-tocopherol and inositol is of value in the treatment of muscular 

 dystrophy, but the claim has not been substantiated by other workers. 



Symptoms of uncomplicated inositol deficiency in man do not 

 appear ever to have been encountered, nor have they apparently 

 been artificially induced in volunteers. 



References to Section 8 



1. J. C. Abels, C. W. Kupel, G. T. Pack and C. P. Rhoads, Proc. 



Soc. Exp. Biol. Med., 1943, 64, 157. 



2. P. Gross and B. M. Kesten, Arch. Derm. Syph., 1941, 47, 376. 



3. A. T. Milhorat and W. E. Bartels, Science, 1945, 101, 93. 



9. HUMAN AND ANIMAL REQUIREMENTS OF 

 INOSITOL 



The importance of inositol in human and animal nutrition has not 

 been established with the same degree of certainty as with other 

 members of the vitamin B complex. It many ways, inositol exhibits 



575 



