NUTRITION OF MICRO-ORGANISMS 



3. V. D. Wiebelhaus, J. J. Betheil and H. A. Lardy, Arch. Biochem., 



1947. 13, 379. 



4. M. R. Stetten and D. Stetten, ibid., 1946, 164, 85. 



5. B. S. Piatt and G. E. Glock, Biochem. J., 1943, 37, 709. 



6. J. Needham, ibid., 1924, 18, 891. 



II. INTESTINAL SYNTHESIS OF INOSITOL 



What evidence there is supports the view that inositol is synthe- 

 sised by the intestinal flora, for D. W. Woolley ^ showed that mice 

 on a diet containing pantothenic acid synthesised inositol, and that 

 bacteria isolated from the intestines of animals that had recovered spon- 

 taneously from alopecia (page 572) synthesised more inositol than 

 micro-organisms from animals that did not recover spontaneously. 

 Furthermore, E. Nielsen and A. Black ^ showed that inositol deficiency 

 could be produced in rats by administration of a sulphonamide. 



References to Section 11 



1. D. W. Woolley, /. Exp. Med., 1942, 75, 277. 



2. E. Nielsen and A. Black, Proc. Soc. Exp. Biol. Med., 1944, 55, 14. 



12. INOSITOL IN THE NUTRITION OF 2VUCRO- 

 ORGANISMS 



As already pointed out (page 564), w^so-inositol is a constituent of 

 the bios complex, and is essential for the growth of Saccharomyces 

 cerevisiae} It stimulates the growth of Nematospora gossypii,^ 

 Rhizopus suinus,^ Eremothecium ashhyii ^ and Trichophyton faviforme ,^ 

 but for most of these organisms it would appear to be a complementary 

 rather than an essential growth factor. It also stimulated the growth 

 of the following yeasts : ^ Candida albicans, Kloeckera brevis, Myco- 

 derma valida, M. vini, Pichia belgica, Saccharomyces bay anus, S. 

 uvarum, Saccharomy codes ludwigii, Schizosaccharomyces pombe, Toru- 

 lopsis stellata, Zygosaccharomyces japonicus and Z. priorianus. It was 

 also essential for Saccharomyces carlsbergensis, S. chevalieri, S. logos, 

 Torula colliculosa and Schizosaccharomyces versatilis.^ 



References to Section 12 



1. E. V. Eastcott, /. Phys. Chem., 1928, 32, 1094. 



2. F. Kogl and N. Fries, Z. physiol. Chem., 1937, 249, 9. 



3. W. H. Schopfer, Compt. rend. Soc. Physique Hist. nat. Geneve, 



1942, 59, 107 ; Helv. Chim. Acta, 1944, 27, 468. 



4. W. H. Schopfer, ibid., 1017. 



37 577 



