276 DIVERS & TAKAHASHI; PHYSIOL. ACTION AMIDOSÜLPH. ACID. 



Addenda, by Edward Divers. Further experiments upon the 

 physiologic.il action of amidosulphonic acid are in progress in Dr* 

 Loew's laboratory in the College of Agriculture at the University, the 

 results of which will appear in the Bulletin of that college. When the 

 above paper was written, the fact had not been ascertained that 

 amidosulphonic acid acts as a reducing agent upon alkaline silver 

 solutions, apparently becoming oxidised into water, nitrogen, and 

 sulphite (this vol., p. 234). This reducing power brings it into 

 association with hydroxy lamine, hydrazine, and amidogen, which 

 Dr. Loew has shown to be so highly poisonous ; though only remotely, 

 because its reducing power is so feeble compared with theirs. The 

 simultaneous generation of sulphite should add to its poisonous action. 



Prof. D. Takahashi, of the College of Medicine of this University 

 has examined the action of sodium amidosulphonate upon vertebrate 

 animals, and has kindly communicated his results to me. He inject- 

 ed 0*2 gram of it subciitaneously into a frog, and intravenously 1*4 

 grams into a young dog, weighing 2 kilogr., in both cases without 

 any injurious effect or any symptoms like those observed by Xencki 

 in experiments with sodium carbamate. Amidosulphonutes are, there- 

 fore, not poisonous to animals. 



