DESCRIPTIONS OF ANTIBIOTICS 



189 



and Trichophyton luentagrophi/tes infections of 

 mice. Absorbed after oral administration (1, 7). 

 Active in rabbits against lihizopus oryzae infec- 

 tions (12), in hamsters on H. capsulatum (8), and 

 in mice on Mucor pusillus (14) and Paracoccidioides 

 brasiliensis (19). Has a protective but variable 

 curative effect in rabbits infected with Asper- 

 ijilhis finnigatiis (20). 



Toxicity: LDso (mice) 280 mg per kg intraperi- 

 toneally (1). Possible renal toxicity in human 

 lieings (13). 



Utilization: Sy.-^temic myco.ses. Coccidioidal and 

 cryptococcal meningitis (11). Cutaneous crj-pto- 

 coccosis, histoplasmosis, and candidiasis (8, 13, 

 18). Certain cases of histoplasmosis, blastomyco- 

 sis, and pulmonary coccidioidomycosis. Effective 

 in one case each of aspergillosis, ocular candidia- 

 sis, and chromoblastomycosis (Hormodendnan 

 pedrosoi) (18). 



References: 



1. Sternberg, T. H. et al. Antibiotics Ann. 



566-591, 1955-1956. 



2. Donovick, R. et al. (iiorn. micr()l:)iol. 2: 



147-159, 1956. 



3. Halde, C. et al. Antibiotics Ann. 123-127, 



1956-1957. 



4. Kozinn, P. J. et al. Antibiotics Ann. 128- 



134, 1956-1957. 



5. Dutcher, J. D. et al. Antil)iotics Ann. 



866-869, 1956-1957. 



6. Larch, H. W. et al. Antibiotics Ann. 918- 



922, 1956-1957. 



7. Halde, C. et al. J. Invest. Dermatol. 28: 



217-232, 1957. 



8. Baum, G. L. et al. Antibiotics & Chemo- 



therapy. 7: 477-482, 1957. 



9. Walters, I). R. ct al. J. Am. Chem. Soc. 



79: 507()-5077, 1957. 



10. Utz, J. P. et al. Antibiotics Ann. 65-70, 



1957-1958. 



11. Furcolow, M. L. and Rubin, H. 17th Conf. 



on Chemotherapy Tuberc, Veterans 

 Admin. February 1958, pp. 309-310. 



12. Chick, E. W. et al. Antibiotics & Chemo- 



therapy 8: 394-399, 1958. 



13. Crounse, R. G. and Lerner, A. B. A. M. A. 



Arch. Dermatol. 77: 210-215, 1958. 



14. Osswald, H. and Seeliger, H. P. R. Arz- 



neimittel-Forsch. 8: 370-374, 1958. 

 15 Donovick, R. Personal communication. 

 October, 1958. 



16. MuUer, W. H. Am. J. Botany 45: 183-190, 



1958. 



17. Sorensen, L. J. et al. Antibiotics Ann. 



920-923, 1958-1959. 



18. Costello, M. J, et al. A. M. A. Arch. Derma- 



tol. 79: 184-193, 1959. 



19. MacKinnon, J. E. Ann. fac. med. Monte- 



video 43: 201-206, 1958 (Biol. Ab.'slr. 33: 

 2813, 1959). 



20. Evans, J. H. and Baker, R. D. Antibiotics 



& Chemotherapy 9: 209-213, 1959. 



Angolamyclii 



Produced by: Streptomyces eurythennus. 



Method of extraction: Culture-filtrate extracted 

 with ethyl acetate at pH 8. Transferred into dilute 

 aqueous acetic acid. Re-extraction with ethyl 

 acetate after being made alkaline with Na^COs . 

 Purification by chromatography on alumina 

 (eluent: chloroform-methanol, 16:1). Crystallized 

 from ether. Can also be precipitated from a 

 warmed ether solution of the crude material by 

 seeding with the pure substance. Recrystallization 

 from benzene on the addition of ether. 



Chemical and physical properties: Basic, lipo- 

 philic sul>stance, probably belonging to the 

 macrolide group (2). Two crystal forms: (a) color- 

 less crystals from benzene-ether; m.p. 133-136°C; 

 (b) colorless needles from diisopropyl ether; m.p. 

 165-168°C. Ultraviolet absorption spectrum maxi- 

 mum at 240 niM (log e = 4.16). Infrared spectrum 

 given in reference 1. [aju = —64° (c = 1.30 per 

 cent in chloroform). Negative Fischback-Levine 

 reaction for carbomycin. C49-.50H87.91O1SN. Acid 

 hydrolysis products include two sugars, neither of 

 which is desosamine. 



Biological activity: Active on certain gram- 

 positive bacteria and Endainoeba histolytica. Not 

 active on gram-negative bacteria, mycobacteria, 

 or 3'easts. Some activity in vivo on Streptococcus 

 pyogenes infections in mice. 



Toxicity: Mice tolerate 500 mg per kg subcu- 

 taneously. 



References: 



1. Corbaz, R. et al. Helv. Chim. Acta 38: 



1202-1209, 1955. 



2. Brink, N. G. and Harman, R. E. Quart. 



Revs. (London) 12: 93-115, 1958. 



Angus tiny ciiis 



Produced by: Stieptoniyces hygroscopicus (1), S. 

 hygioscopicus var. angustniyceticus (4), and S. 

 hygroscopicus var. decoyimine (7). 



Synonym: Related to psicofuranine. 



Method of extraction: Broth adjusted to pH 7.6, 

 stirred with carbon, and filtered. Carbon eluted 

 with 80 per cent aqueous acetone at pH 2.0. 

 Eluates are neutralized and kept in the cold over- 



