332 



DESCRIPTIONS OF ANTIBIOTICS 



at ]:4()(),()()() (22). Treatment of seed slow.s growth 

 and inhibits chlorophyll formation in corn salad 

 (Valerianella locusia) at 2.0~^ leek at 10~*, lentil 

 at 10~^, and radish at 10~^. In Cynara cardunndus 

 (cardoon), root formation is inhibited at 2.10"^ 

 chlorophyll formation at 10'^; but at 2.10"^, no 

 effect on growth. Has a greater to.xic effect on 

 young plants than on seeds, increasing fiavonoid 

 pigment and anthocyanin concentration, and 

 decreasing chlorophyll, /3 carotenoids, and caro- 

 tene (81). Addition of sodivnn potassium chloro- 

 phyll to 500 ppm sprays prevents chlorotic symp- 

 toms in plants (104). Cells: Least injurious doses 

 for human skin and cord cells of the chick embryo 

 in tissue culture are 25 to 50 and 124 /xg per ml, 

 respectively (61). Highest concentration permitting 

 epithelial cell migration in tissue culture is 200 ;ug 

 per ml (107). Minimal concentration causing 

 mitosis inhibition in HeLa cells is 12.5 fxg per ml 

 (99). Inhibits bacteria-free crown-gall tissue at 

 20 MS 1"''' '>''• ''"' '^ot normal tissue (82). Toxic to 

 Allium cepa root cells at 100 ppm in 12 hours (26). 



Utilization: Clinically useful in infections 

 caused by gram-positive and gram-negative bac- 

 teria, amoebae, spirochaetes, rickettsiae, and 

 psittacosis group (93). 



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