Appendix 



List of Additional Antibiotics and 

 Antibiotic Preparations 



A number of other antibiotics and antibiotic 

 preparations are described in the literature, most 

 of which appeared while this compilation was 

 being completed. They are briefly listed here. 



2-Acetyl-2-decarboxamide-oxy tetracycline: Oxy- 

 tetracycline derivative. Produced b}'- S. riniosus. 

 Its antibiotic spectrum is similar to o.xytetra- 

 cycline, but is less active. (Hochstein, F. A. et al. 

 J. Am. Chem. Soc. 82: 5934-5937, 19(i0.) 



Artiphenol: A biologically inactive glutarimide 

 produced by cycloheximide-nonactin-producing 

 strains of Streptomyces. C15H17O4N; m.p. 199- 

 200°C. Ultraviolet maxima at 215, 264, and 354 

 niju in methanol. (Highet, R. J. et al. Helv. 

 Chim. Acta 42: 1523-152G, 1959.) 



Akitamycin: An antifungal tetraene. (Soeda, M. 

 et al. J. Antibiotics (Japan) 12B: 293-299, 1959.) 



Atnidinomycin: A basic antibiotic, produced by 

 a Streptomyces; active against gram-positive bac- 

 teria. The sulfate in aqueous solutions absorbs 

 light at 211 to 212 m/^. Structure of the sulfate: 



H2N, 



J— CO— NH— CH2— CH,- 



NH 



II 

 -C • 



I 

 NHo 



H2S(34 



(Nakamura, S. et al. J. Antibiotics (Japan) 

 13 A: 362-365, 1960.) 



Amminosidin: An antibiotic of the neomycin- 

 catenulin-kanamycin type, produced by S. cresto- 

 myceticus. Sjmonyms: crestomycin, antibiotic 1600 

 F.I., antibiotic F.I. 5853, formiglucine. (Arca- 

 mone, F. et al. Giorn. micr(jl)iol. 7: 251-272, 

 1959; Calandi, C. and Bartolozzi, G. Riv. clin. 

 pediat. 64: 269-284, 1959.) 



Amycin: A basic water soluble antibiotic pro- 

 duced by a strain of S. lavendulae. Active against 

 bacteria resistant to streptomycin, neomycin, 

 vioniycin, and streptothricin. Negative Hakaguchi 

 and positive ninhydrin reactions. LD50 (mice) = 

 120 mg per kg intraperitoneally. (Craveri, R. Ann. 

 Microbiol. Enzimol. 10: 115-121, 1960.) 



Amylocyanin: A litmus-like pigment produced 

 by Streptomyces coelicolor. Has antifungal proper- 

 ties. (Miiller, R. Centr. Bakteriol. Parasitenk., 

 Abt. I Orig. 46: 195-212, 1908.) 



Antibiotic J^: Basic antibiotic produced hy S. 

 griseoflavus; about 2.5 times more toxic than strep- 

 tomycin. (Heki, M. et al. Japan. Med. J. 3: 41- 

 47, 1950.) 



Antibiotic A.E. 56: An antifungal heptaene, 

 closely related to aj'factin and produced by a spe- 

 cies of Streptomyces. (Staron, T. and Faivre- 

 Amiot, A. Compt. rend. 250: 1730-1732, 1960.) 



Antibiotic H 18: Basic antibiotic produced by 

 a chromogenic Streptomyces species. Delayed tox- 

 icity. Reineckate; m.p. 181-182°C. (Hosoya, S. et 

 al. J. Antibiotics (Japan) 2: 550, 1948.) 



Antibiotic of Vernon and Dye: An antibiotic 

 with a broad antibacterial s])ectrum, produced by 

 a white-spoi'ed Streptomyces. (Vernon, T. R. and 

 Dye, M. H. New Zealand J. Agr. Research 2: 

 982-989, 1959.) 



Antibiotic P 9: An antibiotic produced by a 

 Streptomyces. It is nonphytotoxic and is trans- 

 located in plants. Active in vivo against certain 

 fungi. (Davis, D. et al. Phytopathology 50: 841- 

 843, 1960.) 



Antibiotic PA 96: Chemically stable antiviral 

 substance. (Ambrus, J. L. et al. Antibiotics & 

 Chemotherapy 3: 16-22, 1953; Chinn, B. D. 

 Proc. Soc. Exptl. Biol. Med. 80: 359-360, 1952.) 



Antibiotic complex of Sgarzi et al.: An antibiotic 

 active against gram-positive bacteria. Hydroly- 

 sate yields amino acids. Ultraviolet light-absorp- 

 tion maximum at 282 nifj,. (Sgarzi, B. et al. Na- 

 ture, London 187: 1029-1030, 1960.) 



Antibiotic of Raya: A water soluble antibiotic, 

 produced b}' a Streptomyces. Active against bac- 

 teria, mainly Brucella and fungi. (Raya, J. M. 

 Rev. farm. (Buenos Aires) 101: 151-157, 1959; 

 Chem. Abstr. 55: 1789g, 1961.) 



Antibiotics Mil and 719: Produced by strains 

 of Streptomyces violaceus. Dark red substances 

 soluble in eth3-l alcohol. Can partiallj' inactivate 



410 



