APPENDIX 



411 



influenza viruses in vitro. Effective in suppressing 

 influenza viruses (A, Ai , and A2) in chick embryo. 

 (Purer, N. M. Antibiotiki 4(3): 30-36, 1959.) 



Antibiotics with pH indicator properties: In the 

 following papers, poorly described antibiotics 

 with litmus-like properties have been discussed: 

 Sanchez -Marroquin, A. and Zapata, M. Appl. 

 Microbiol. 2: 102-107, 1954; Conn, J. E. J. 

 Bacteriol. 46: 133-149, 1943; Oxford, A. E. J. 

 Hactcriol. .il: 267-269, 1946; Kriss, A. E. 

 Compt. rend. acad. sci. U.R.S.S. 4: 283-287, 1936; 

 Frampton, V. L. and Taylor, C. F. Phytopa- 

 thology 28: 7, 1938. 



Antifungal antibiotics 2814P and 2814H: Two 

 polyenic antifungal antibiotics produced by a 

 strain of Streptoniyces. P is a pentaene and H is a 

 heptaene. (Thrum, H. et al. Xaturwissenschaften 

 47: 474, 1960.) 



Antifungal antibiotic S 39: A water-soluble 

 antifungal substance produced l)y strains of Strep- 

 toniyces absorhing light at260mju. (Gopalkrishnan, 

 K. S. et al. Hindustan Antibiotics 2: 7, 1959.) 



Antitumor antibiotic NSC A-649: An antitumor 

 antibiotic with activity against gram-positive bac- 

 teria. Chemically the substance has properties 

 similar to the magnesium salt of aureolic acid, 

 antibiotic M5-18903, aburamycin, and antibiotic 

 L A 7017. (Schmitz, H. et al. Antil)i()tics & Chem- 

 otherapy 10: 740-746, 1960. j 



A t/ainycins: A mixture of antitumor substances 

 produced l)y a Streptoniyces. One of these com- 

 ponents, ayamycin As , is an orange-yellowish 

 substance which absorbs light at 220, 320, and 

 430 m;u in methanol. It has slight activity against 

 gram-positive bacteria. (Sato, K. J. Antibiotics 

 (Japan) ISA: 321-326, 1960; Tanno, K. J. Anti- 

 l)iotics (Japan) ISA: 391-400, 1960.) 



Bacteriolytic factors: Produced by Streptoniyces 

 albus. (McCarthy, M. J. Exptl. Med. 96: 555- 

 580, 1952; Floch, H. Compt. rend. soc. Inol. 

 143:449-450, 1949.) 



Capacidin: A pentaenic antifungal antibiotic 

 produced by a strain of Streptoniyces. (Brown, R. 

 and Hazen, E. L. Antiliiotics & Chemotherapy 

 10:702-708, 1960.) 



Carzinostatin: An antitumor substance produced 

 l)y a Streptoniyces related to S. albus. It is com- 

 po.sed of two fractions, one soluble in methanol 

 and one insoluble in methanol, which have a syner- 

 gistic action against Sarcina liitea. (Shoji, J. J. 

 Antibiotics (Japan) 14A: 27-33, 1961.) 



Cinerubins: Antitumor substances similar to 

 rhodomycin, produced by various strains of Strep- 

 toniyces. (Corbaz, R. et al. Arch. Mikrobiol. 

 2.^: 325-332, 1957; Loustalot, P. et al. Ann. N. Y. 



Acad. Sci. 76: 838-848, 1958; Ettlinger, L. et al. 

 Chem. Ber. 92:1867-1879,1959.) 



Datemycin: A narrow spectrum antifungal anti- 

 biotic (active against some strains of Candida) 

 probably produced by an actinomycete. Ultra- 

 violet maxima at 235 and 247 m/u. (Kuroya, M. 

 and Koyama, Y. Japanese Patent 6648, July 31, 

 1959, cited in Chem. Abstr. 34: 832f, 1960.) 



Dihydro E 73: A chemical derivative of antitu- 

 mor substance E 73. Has some activity in certain 

 cancer patients. (Wright, J. C. et al. Cancer 

 Chemotherapy Repts. 8: 7-17, 1960.) 



Emimycin: An antibiotic with poor activity 

 against Ijacteria and fungi. Produced by a strain 

 of Streptoniyces similar to S. griseochroniogenes. 

 Water soluble, U.V. max. (methanol) at 222-223, 

 276 and 330-332 m^. (Terao, M. et al. J. Antibiotics 

 (Japan) ISA: 401-405, 1960.) 



Erygrisin: A water soluble pH indicator antibio- 

 tic which is mainly active against gram-positive 

 bacteria. LD50 (mice) = 50 mg per kg subcu- 

 taneously. Produced by Streptoniyces erytlirogris- 

 eus. (Lyra, F. D. A. et al. Ref. Inst Antibioticos, 

 Pernambuco 2: 99-107, 1959.) 



Eurotin: An antifungal antibiotic i)roducetl l)y 

 S. griseus. Shows weak light-absorption maxima 

 at 365 and 385 to 390 m/Li in aqueous solutions. 

 (Hosoj-a, S. Tohoku Igaku Zassi 6: 285-292, 

 1959.) 



Ferromycin: A new antibiotic produced by »S'. 

 myanaensis. Called ferromycin because ferrous 

 sulfate is needed for production. Basic antibiotic, 

 decomposes at 188°C, C.21H54O14N7.2HCI hydro- 

 chloride. Active against gram-positive and gram- 

 negative bacteria. (Taguchi, H. and Yoshikawa, 

 K. J. Perm. Technol. 39:44-52, 1961.) 



Frenolicin: An antibiotic containing no nitro- 

 gen, and having very little activity against bac- 

 teria and fungi. Produced by »S. fradiae. (Van 

 Aleter, J. C. et al. Conf. on antimicrobial agents, 

 Washington, D. C, 1960.) 



Geminimycin: An antil>iotic composed of two 

 biologically inactive components. Mixture of the 

 two components is active against gram-positive 

 bacteria. (Rao, K. V. et al. Conf. on antimicro- 

 bial agents, Washington, D. C, 1960.) 



Heptamycin: A heptaenic antifungal antil)iotic 

 produced by a Streptoniyces. (Henis, Y. et al. J. 

 Gen. Microbiol. 23: 345-355, 1960.) 



HON: A water soluble nonto.xic antimycobac- 

 terial antibiotic produced by Streptoniyces akiyo- 

 shiensis U.V. max. at 271 m/j.. CsHgOjN (5-hy- 

 droxy-7-oxo-L-norvaline). (Kanazawa, K. et al. 

 Am. Rev. Resp. Dis. 81: 924, 1960; Tatsuoka, S. 

 et al. J. Antibiotics (Japan) 14A: 39-43, 1961.) 



