412 



DESCRII'TIOX.S OF ANTIBIOTICS 



Imoticidin: An antibiotic produced l).v strains 

 of S. albus. Active against gram -positive bacteria 

 and fungi. (Inouye, T. et al. Ber. Ohara Inst, 

 landwirtsch. Biol. Okayama Univ. 11: '.)5-131, 

 1959; Nogaku Kenkyu 46: 120-128, 1959.) 



Lankamycin and Lankacidin: Two neutral, 

 colorless, weakly antibacterial substances pro- 

 duced by a strain of *S. violaceoniger . (Gaumann, 

 R. et ai. Helv. Chim. Acta 43: 601-G06, 1960.) 



Marinamiicin: Weak activity against gram-posi- 

 tive bacteria and fungi. (8oeda, M. et al. J. Anti- 

 biotics (Japan) 12B: 300-304, 1959.) 



Minomycin: Orange antibiotic produced by a 

 Streptomyces; pH indicator. Active against gram- 

 positive bacteria and certain tumors. Light-ab- 

 sorption maxima at 241, 277, and 444 ni/x in metha- 

 nol. (Ni.shimura, H. et al. J. Antibiotics (Japan) 

 13 A: 327-334, 1960.) 



Mithramycin: A to.xic antitumor antiliiotic. 

 Synonyms: antibiotics PA 144 and NSCA 2371. 

 (Curreri, A. R. et al. Cancer Chemotherapy 

 Repts. 8: 18-22, 1960; Parker, G. W. et al. Can- 

 cer Chemotherapy Repts. 8: 23-26, 1960.) 



Monomycin: An antibiotic of the neomycin 

 group produced by Streptomyces circulatus var. 

 monomycini. (Gause, G. F. et al. Antibiotiki 

 5(4): 3-37, 1960.) 



Porfiromycin: An antibacterial, purple sub- 

 stance produced by Streptomyces ardus. (Deboer, 

 C. et al. Conf. on antimicrobial agents, Wash- 

 ington, D. C, 1960.) 



Primocardin: A neutral antitumor sul)stance 

 with a modest amount of antibacterial activity, 

 produced by Nocardia vkayae. Water soluble. 

 U.V. max. (0.05 N HCl) 253 m^. CsHi.NoOs . 

 (Sumiki, Y. et al. J. Antibiotics (Japan) 13A: 416, 

 1960.) 



Pyrromycin: A red antibiotic produced bv a 

 Streptomyces. Active against gram-positive bac- 

 teria. In chloroform, light-absorption maxima at 

 498, 518, and 533 m^, with inflections at 395, 415, 

 469, and 482 ra/j.. Related to rhodomycin. (Brock- 

 mann, H. et al. Chem. Ber. 92: 1904-1909, 1959.) 



9-0-D-Ribofuranosylpurine: This nucleoside had 

 previously been found in Agaricus neburaris; is 

 also found to be produced by a Streptomyces . It is 

 moderately active against some mycobacteria 



and fungi. (Isoiio, K. and Suzuki, S. J. Anti- 

 biotics (Japan) 13A: 270-272, 1960.) 



Teruchiomycin: A macrolide antibacterial sub- 

 stance (C2SH43XO16) produced by S. eurocidiciis. 

 (Umezawa, H. et al. Japanese Patent 850, February 

 13, 1958; cited in Chem. Abstr. 52: 20921, 1958.) 



Teleocidin: Produced by a variant of S. medio- 

 cidicus. Extracted from mycelium by ethanol in 

 form of a white crystalline powder. Highly toxic 

 to various aciuatic organisms, notably Japanese 

 killifish (Coryzias latipes) and mice; no inhibiting 

 effect upon the growth of microorganisms. (Taka- 

 shima, M. and Sakai, H. Bull. Agr. Chem. Soc. 

 Japan 24: 647-651 , 652-655, 1960.) 



Theiomycetin: An antibiotic produced l)y a 

 Streptomyces, active against various bacteria and 

 fungi. It contains sulfur, and melts at 230°C. 

 (Shibata, M. Takeda Kenkyusho Nempo 18:44- 

 48, 1959, cited in Chem. Abstr. 54: 19840c, 1960.) 



Toyamycin: An antifungal tetraene. (Ishibashi, 

 H. 104th Japan. Conf. on Antibiotics, May, 

 1957.) 



Tundromycin: A chemically unstal)le antibiotic 

 produced by S. globisporus tiindromycini. It is 

 characterized by a narrow spectrum, and is ac- 

 tive against strains of staphylococci and sarcinae. 

 (Kovalenkova, V. Bull. Moscow Soc. Natural- 

 ists, Ser. Biol. 62(2): 79, 1957.) 



Tylosin: A weakly basic substance soluble in 

 organic solvents. Produced by a strain of S. 

 fradiae. Acid hydrolysis yields mycarose and an 

 antimicrobial compound, desmycosin. Active 

 against viruses, gram-positive and gram-negative 

 bacteria. (Abstr. 135th Meeting Am. Chem. Soc. 

 16C, 1959.) 



Virtosin: An antifungal antibiotic produced by 

 Streptomyces olivochromogenes. Positive Sakagu- 

 chi, negative ninhydrin reaction. (Miyake, A. et 

 al. Japanese Patent 6149, August 10, 1957, cited 

 in Chem. Abstr. 52: 20919b, 1958.) 



Yunamycin: An antifungal antibiotic (probably 

 a tetraene). Ultraviolet absorption spectrum max- 

 ima at 290, 304, and 320 m^. Produced by Strepto- 

 myces fungicidicus. (Umezawa, H. and Nagase, 

 M. Japanese Patent 3.392, May 7. 1959, cited in 

 Chem. Abstr. 53: 20708d, 1959.) 



Zygomycin A: A paromomycin-like antibiotic. 

 (Kanazawa, K. et al. Am. Rev. Resp. Dis. 81.- 924, 

 1960.) 



