ANTIBACTERIAL SUBSTANCES FOR TREATMENT OF INFECTIONS 185 



isms of the body by inhibiting the growth of the infecting organisms. In general, 

 except when the lesions produced by the infecting organisms are inaccessible 

 to the penicillin introduced, the in vivo potency of penicillin parallels the in vitro 

 potency. The first experimental infections successfully treated with penicillin 

 were of mice infected intraperitoneally with Str. pyogenes and Staph, aureus, and 

 intramuscularly with CI. septicum (Chain et al. 1940). It was later shown to be 

 effective in mice infected with virulent pneumococci (Hobby et al. 1942c) ; with 

 N. meningitidis (Dawson et al. 1943) ; with CI. welchii (Mcintosh and Selbie 1943a, 

 McKee, Hamre and Rake 1943, Hac and Hubert 1943, 1944) ; and with Staph, 

 aureus (Powell and Jamieson 19426). Robinson (1943) was unable to demonstrate 

 any action on mice infected with Myco. tuberculosis, Trypanosoma equiperdum or 

 influenza virus. 



Little information is yet available on the effect of penicillin on virus infections. 

 The evidence so far obtained suggests that most viruses are insusceptible, but 

 that two viruses belonging to the lymphogranuloma group (see Chapter 85), namely 

 mouse pneumonia virus and the lymphogranuloma virus itself, constitute possible 

 exceptions to this rule. 



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