ACTINOBACILLUS ACTINOIDES 393 



weeks very tiny, elevated, pointed-like colonies may appear on the slant. Growth may 

 be obtained on agar to which a piece of guinea-pig's spleen has been added. No growth 

 on ordinary media or on ascitic fluid. Non-pathogenic for laboratory animals on experi- 

 mental injection. Subcutaneous injection into calves causes a large necrotic swelling 

 with caseous contents ; ulceration occurs in 4 weeks. Intratracheal injection into calves 

 causes small necrotic foci in the lungs, identical with those observed in the natural disease 

 (Smith 1921a, see also Jones 1922). The fact that it has been isolated from the lungs 

 of white rats suffering from pneumonia (Jones 1922) suggests that it may be a natural 

 parasite of these animals. For further references to this organism see Smith (1921a, b). 

 A similar organism, differing only in minor particulars has been isolated from the middle 

 ear of white rats, in which it was causing suppuration (Nelson 1930, 1931). The resem- 

 blance of Actinobacillus actinoides to Streptobacillus moniliformis (see p. 381) has been 

 noted by Dienes and EdsaU (1937) ; but in view of its reported lack of pathogenicity for 

 laboratory animals and its bacillary morphology in the lungs of calves, it is probably 

 wiser to treat it separately for the moment. 



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