THE FRIEDLANDER GROUP 



673 



TABLE 43 



Anti-rouqii Sebum, or an Anti-protein Serum, acting on Smooth Capsulatbd and Rough 



NON-OAPSULATKD BaOILLI. 



It is of interest to note that the B type of Friedlander's bacillus is similar 

 immunologically to Type II pneumococcus. The specific polysaccharide in the 

 B type, in conjunction with the protein fraction, stimulates the formation of an 

 immune serum that will agglutinate pneumococcus Tyj^e II, and will protect 

 mice against infection with it ; similarly pneumococcus Type II serum will 

 agglutinate Friedlander Type B and protect mice against infection with it. The 

 polysaccharides in the two organisms appear to be closely alike, though not 

 absolutely identical (Avery et al. 1925). A Friedlander Type B organism will not, 

 however, absorb the agglutinins from pneumococcus Type II serum, nor a pneu- 

 mococcus Type II organism from a Friedlander Type B serum. This probably 

 indicates that though the polysaccharides are alike, the protein fractions of the 

 organisms are different. 



According to Tomasek (1925), Quasi (1926), Prica (1930), and Neuber (1934) the 

 rhinosderoma bacillus can be distinguished by agglutination and complement fixation 

 from Friedlander's and the ozaena bacillus. Morris and Julianelle (1934), however, who 

 examined 10 strains of the rhinosderoma bacillus, were unable to distinguish this organism 

 antigenically from strains of Friedlander's Type C. This observation is supported to some 

 extent by Goslings and Snijders (1936), who found that aU rhinosderoma strains had 

 the same capsular and the same somatic antigens ; the capsular antigen was practically 

 indistinguishable from the Type C Friedlander antigen. 



According to Juhanelle (1935) the ozcena bacillus can be distinguished by agglutination 

 and absorption of agglutinins from Friedlander and rhinosderoma bacUU. Of 19 ozaena 

 strains studied, 12 feU into one group, 2 into another, and the remaining 5 were anti- 

 genically heterogeneous. Goshngs and Snijders (1936), likewise, concluded that there 

 were two, and possibly three, different capsular antigens among ozaena strains ; these 

 they labelled D, E, and (F). All strains, however, appeared to share a common somatic 

 antigen. Wielenga (1937) reports on three strains that possessed the somatic antigen 

 of Bad. ozcence and the Type C capsular antigen of Bad. friedldnderi. 



Prasek and Prica (1933) state that they have been successful in extracting a soluble 

 specific carbohydrate-containing substance, which is probably a galactan, from the capsules 

 of the ozaena and the rhinosderoma bacillus. The substances from the two organisms 

 were quite distinct, and showed no cross-precipitation when tested against the heterologous 

 immune sera. They were likewise distinct from the polysaccharide extracted from a 

 Friedlander's bacillus. 



The relation between Friedlander and aerogenes strains is still obscure. JuhaneUe 

 (1937), who studied 3 strains of Bad. aerogenes, found that they shared a common somatic 



P.B. Z 



