BACTERIOLOGY AND IMMUNITY 



Antibodies, modification of, by chemical means, 

 247 

 by enzymes, 247 

 by physical means, 247 

 molecular weight of, 243, 245 

 monospecific, homogeneity of, 249 

 natmal, 1075-1097 



age in relation to, 1091 

 antibacterial antibodies, 1085, 1092- 

 1096 

 agglutinins, 1085 et seq. 



Brucella infections, 1699 

 in latent Salmonella infec- 

 tions, 1533 

 bactericidins, 1086 

 complement-fixing, 1086 

 immunological significance of, 



1095 

 origin of, 1092-1095 

 antitoxins, 1075 



in blood of normal horses, 1084 

 immunological significance of, 



1084 

 origin of, 1076-1084 



environment in relation to, 

 1080 et seq. 

 rate of development under dif- 

 ferent conditions, 1083 

 viricidal, 1226 

 possible inclusion of antigens in, 1127 

 protein nature of, 242 et seq. 

 purification of, 243 

 reagins, relation of to, 1157 

 serum-globulins, relation of to, 244 

 site of formation of, 1101-1106 

 unity or diversity of, 248-252, 285 

 valency of, 250 

 various, names of, 195 

 Antibody-forming apparatus, 1101-1131. See 



Antibodies, formation of 

 Antibody globulin, 242 



varieties of, 245 

 Anti-endotoxins, 1008 



failure of law of multiple proportions in 

 action of, 1009 

 Antiformin, use of in obtaining pure cultures, 



354, 418, 1321 

 Antigen-antibody reactions, 192-265 



adsorption in, 199, 216^219, 226, 240, 273- 



275 

 agglutination, 211 



cohesive force in relation to, 214 

 electric charge in relation to, 213 

 electrolytes in relation to, 213 

 in diagnosis. See under individual 



diseases 

 optimal antigen — antibody ratio in 



relation to, 212 

 potential difference in relation to, 214 

 tests of lattice hypothesis in, 221 

 alexine, 193, 196 



antigen and antibody, combination of, in 

 varying proportions, 205, 216, 219, 227 

 240 

 antigenic specificity, surface structure in 



relation to, 263 

 Arrhenius and Madsen's theory of, 199, 239 



Antigen-antibody reactions, bactericidins, 228 

 bacteriolysis, 192, 228 



Neisser-Wechsberg phenomenon in, 



228 

 Pfeiffer's reaction, 192, 1050, 1425 

 bacteriotropins, 194, 235 



complement, relation of to, 236 

 electric charge in relation to action 



of, 235 

 relation of to opsonins, 235 

 Bordet's theory of, 199 

 capsular swelling reaction, 241 

 combination in varying proportions, 205 

 complement, 193, 196 

 nature of, 229 

 unity or diversity of, 229 

 complement fixation, 232 



in diagnosis. See under individual 



diseases 

 optimal conditions for, 233 

 relation of to precipitin reaction, 233 

 differences in antigenic structure in rela- 

 tion to, 285 

 efficacy of in vivo, 1061 

 Ehrlich's theory of, 196 

 electrolytes, effect of on, 200, 207, 211, 



213, 226 

 Freimdlich isotherm in relation to, 218 

 hcemolysis, 193, 224 



supposed role of amboceptors in, 225 

 temjDerature, effect of, on, 227 

 haptens, inhibition of precipitation by, 257 

 hydrophile and hydrophobe states in rela- 

 tion to, 209 

 lattice hypothesis of, 208, 220 

 law of multiple proportions in, 217 

 mass law in, 219 



microscopic appearance of specific aggre- 

 gates, 223 

 miscellaneous manifestations of, 240 

 nature of union in, 263 

 opsonins, 194, 235 



complement, relation of to, 236 

 electric charge in relation to action of, 



235 

 relation of to bacteriotropins, 235 

 optimal antigen : antibody ratio in rela- 

 tion to, 201 et seq., 212 

 relation of constant-antigen ratio to 



constant- antibody ratio, 203-207 

 relation of to chemical equivalence, 

 204 

 precijDitin reaction, 200 



effect of various factors on, 200 



electrolytes, effect of, on, 200 



in standardization of antiimcumo- 



coccal serum, 1681 

 optimal antigen-antibody ratio in 



relation to, 201 

 relation of to complement fixation, 



233 

 tests of lattice hypothesis in, 221 

 qualitative aspects of, 242-265 

 quantitative aspects of, 201-241 

 reversibility of, 216 



effect of salts on, 214 

 " side-chain " theory of, 196 



