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against as glanders, but no diagnostic test — like the mallein test 

 — has as yet been evolved. 



During the beginning of February a call was received from 

 the adjoining plantation to the north. Upon arrival a large plan- 

 tation mule which had been isolated was found to be badly 

 affected with both the nasal and cutaneous form of the disease. 

 There was no fever and no submaxillary swelling, nor did the 

 animal react to either the intradermal nor the ophthalmic mal- 

 lein test — three facts sufficient to establish the diagnosis of 

 epkootic lymphangitis when considered in connection with the 

 nasal discharge and the corded and noduled lymph vessels on 

 neck and hind-legs. On this plantation stable and feed condi- 

 tions were even worse than on the one above mentioned. The 

 stables were badly located, practically no drainage, and the 

 floors were absolutely prohibitive against an animal lying down 

 to rest. No cane tops, and grain impossible to obtain. Soggy 

 rank grass, chopped, alfalfa meal and molasses constituted the 

 feed on which the animals were supposed to work. A most thor- 

 ough disinfection of the whole stable was begun at once, the 

 disinfectant recommended by the Board of Health being em- 

 ployed in connection with quicklime for the floors. 



The next case developed in an old mule which was kept in a 

 sling on account of a badly injured hind-leg. Nodules and cords 

 appeared all over the body and the animal was shot. There were 

 no nasal symptoms. A week later two cases developed in quick 

 succession, one in a separate stable across a gulch from the rest 

 of them and the other in one of the already disinfected stables. 

 Both were immediately segregated and mallein tested by three 

 distinct methods, the intradermal, the ophthalmic and the sub- 

 cutaneous test, but neither reacted in the slightest degree. One 

 of these cases is remarkable in that it recovered, at least tem- 

 porarily. The right hind leg was diffusely swollen and from a 

 wound on the inside of the thigh flowed a profuse creamy white 

 discharge, mixed with streaks of blood. As there were no 

 cords or nodules and as it was a valuable animal, treatment was 

 undertaken. This consisted simply in repeated ablutions of the 

 wound with a strong disinfecting solution, and the application of 

 mercuric ointment. In the course of two weeks the wound had 

 healed and while there still remained some swelling of the leg 

 the animal was able to go to work. Whether this is a permanent 

 cure remains to be seen. On the other hand the case may have 

 been one of simple suppurative lymphangitis which however is 

 not likely on account of the color of the pus. 



Mule No. 4 was a typical case, nasal as well as cutaneous. In 

 order to dispel the last doubt as to the diagnosis a couple of 

 guinea pigs had been secured. These animals are highly sus- 

 ceptible to glanders and will, when inoculated with the nasal dis- 

 charge, develop the disease in from 6 to 11 days. Both were 

 inoculated intra-abdominally with a syringe full of the nasal 

 discharge of the mule, dissolved in normal salt solution. With 



