VOL. 4 (1950) 



METABOLISM OF NUCLEATED RED CELLS 



287 



Different oxidation processes, however, are influenced to a very different degree. The 

 oxidation of glucose suffers much more than the basic oxidation. M/480 sodium oxalate 

 suppresses the additional respiration by glucose 80-100%, the basic only 0-15%. 

 Essentially the same relation is vahd for M/25 Na2S04, M/50 Na phosphate and M/1700 

 Na ribonucleate. The oxidation of succinate is less suppressed than that of glucose but 

 more so than that of a-ketoglutarate and citrate. 



e) Synergy between Mg and Ca and anions in their inhibitory effects. Effects of ions 

 on colloidal particles are in general counteracted by ions of opposite charge if the 

 effects are due to neutralization of electric charges. It is, therefore, surprising that 

 inhibitory effects of anions on the metabolism of red cells are not eliminated or de- 

 creased, but on the contrary strongly enhanced by Mg and Ca (other multivalent cations 



TABLE V 



SYNERGY BETWEEN Mg''"'' AND Ca*"'' AND MULTIVALENT ANIONS IN THEIR EFFECTS ON THE AEROBIC 

 GLYCOLYSIS OF THE HEMOLYSATE IN PRESENCE OF GLUCOSE. TEMP. 25°. TIME! EXP. I-V 4 HOURS, 



EXP. II 2 HOURS 



References p. 2g2. 



