OVARY AS ORGAN OF INTERNAL SECRETION 75 



the clitoris are produced by ovariectomy of the immature 

 mouse, a fact which emphasizes the vestigial nature of the 

 clitoris in this animal. 



These effects of ovariectomy are now almost universally 

 ascribed to the removal of ovarian influence. Early workers, 

 such as Hofmeier (308), were inclined to attribute the effect to 



■^<i^'-" 



; M ' . . 



^^^•a. 



d.l. 







Fig. 39. — Vagina of Mouse after Pre-Pubertal Ovariectomy, 



SHOWING rudimentary CONDITION. 



d.l. debris in lumen; w.r. wall of rectum. 



disturbance of the vascular supply of the uterus by the opera- 

 tion, or to interference with the nervous connections, as sug- 

 gested by Sokoloff (588). Many workers, however, have taken 

 specific precautions against such possible effects, and, in any 

 case, the operation of ovariectomy can hardly interfere with 

 the vascular supply of the mammary glands. Similarly, another 

 early hypothesis, that hysterectomy causes atrophy of the ovary, 

 is now untenable (114). 



{b) OVARIAN TRANSPLANTATION 



The facts discussed in the previous section make it clear that 

 the development and maintenance of the accessory organs of 



