74 INTERNAL SECRETIONS OF THE OVARY 



results were obtained by Bucura (109) on the rabbit, by 

 Marshall and Jolly (452, 453) on rats, by Tandler and Keller 

 (609) on cows, and by Halban (260) on guinea-pigs. This last 

 author also states that the mammary gland fails to develop 

 after pre-pubertal ovariectomy. 



Ovariectomy in the human leads to the degeneration of 

 uterus, vagina, and mammary glands, or, if the operation is 

 pre-pubertal, to the non-development of these organs. In the 



™ Ob **.*• 







Fig. 38. — Uterus of Mouse after Pre-Pubertal Ovariectomy, 



SHOWING rudimentary CONDITION. 



case of the mammary glands, however, it is necessary to make a 

 qualification; there is some evidence that if the gland is secreting 

 at the time of the operation, the secretion may be prolonged. 

 In the mouse (508) the effects of pre-pubertal ovariectomy 

 (at three weeks old) are remarkable. Two months after the 

 operation the uterus is not only undeveloped, but has actu- 

 ally degenerated from the pre-pubertal state, being only about 

 •I mm. in diameter. Microscopically it consists of a ' stroma,' 

 three to four cells thick, surrounded by a few layers of muscle 

 fibres. The changes in the vagina are equally definite. Though 

 about the same size as the pre-pubertal organ, the vagina 

 after ovariectomy is collapsed, the component layers are 

 atrophic, and the lumen is blocked by debris. No effects on 



